TY - JOUR
T1 - A complete pathological response to treatment in a young patient with locally advanced minimal deviation adenocarcinoma of the uterine cervix undergoing chemoradiation followed by radical surgery
AU - Ferrandina, Maria Gabriella
AU - Carbone, Arnaldo
AU - Macchia, Gabriella
AU - Petrillo, Marco
AU - Lucidi, Alessandro
AU - Morganti, Alessio Giuseppe
PY - 2011
Y1 - 2011
N2 - Minimal deviation adenocarcinoma (MDA) is a very rare variant of cervical adenocarcinoma. This pathological entity is composed of mucinous very-well-differentiated glands deeply invading cervical stroma, and often surrounded by a desmoplastic reaction. Despite its benign histological appearance, MDA is typically characterized by aggressive clinical behavior and by relevant difficulties in achieving a final diagnosis. Moreover, the intrinsic chemotherapy resistance, as well as the frequent failure of radiotherapy approaches has raised the need to investigate the efficacy of multimodal strategies for the treatment of MDA patients. Here, we report a case of locally advanced MDA of the uterine cervix in a very young woman, who was successfully treated with concomitant chemoradiation followed by radical surgery.
AB - Minimal deviation adenocarcinoma (MDA) is a very rare variant of cervical adenocarcinoma. This pathological entity is composed of mucinous very-well-differentiated glands deeply invading cervical stroma, and often surrounded by a desmoplastic reaction. Despite its benign histological appearance, MDA is typically characterized by aggressive clinical behavior and by relevant difficulties in achieving a final diagnosis. Moreover, the intrinsic chemotherapy resistance, as well as the frequent failure of radiotherapy approaches has raised the need to investigate the efficacy of multimodal strategies for the treatment of MDA patients. Here, we report a case of locally advanced MDA of the uterine cervix in a very young woman, who was successfully treated with concomitant chemoradiation followed by radical surgery.
KW - Adenocarcinoma
KW - Adult
KW - Chemotherapy, Adjuvant
KW - Combined Modality Therapy
KW - Diagnosis, Differential
KW - Female
KW - Humans
KW - Magnetic Resonance Imaging
KW - Radiotherapy, Adjuvant
KW - Uterine Cervical Neoplasms
KW - Adenocarcinoma
KW - Adult
KW - Chemotherapy, Adjuvant
KW - Combined Modality Therapy
KW - Diagnosis, Differential
KW - Female
KW - Humans
KW - Magnetic Resonance Imaging
KW - Radiotherapy, Adjuvant
KW - Uterine Cervical Neoplasms
UR - http://hdl.handle.net/10807/14223
UR - http://www.karger.com/article/abstract/327938
U2 - 10.1159/000327938
DO - 10.1159/000327938
M3 - Article
SN - 0378-7346
VL - 72
SP - 141
EP - 144
JO - Gynecologic and Obstetric Investigation
JF - Gynecologic and Obstetric Investigation
ER -