A comparison of laser with radiofrequency ablation for the treatment of benign thyroid nodules: a propensity score matching analysis

Claudio Maurizio Pacella, Giovanni Mauri, Roberto Cesareo, Valerio Paqualini, Roberto Cianni, Pierpaolo De Feo, Giovanni Gambelunghe, Bruno Raggiunti, Doris Tina, Maurilio Deandrea, Pier Paolo Limone, Alberto Mormile, Massimo Giusti, Silvia Oddo, Gaetano Achille, Enrico Di Stasio, Irene Misischi, Enrico Papini

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

60 Citazioni (Scopus)

Abstract

Purpose: To compare technique efficacy and safety of laser ablation (LA) and radiofrequency ablation (RFA) in treatment of benign thyroid nodules. Materials and methods: Institutional review board approval was obtained, and patients’ consent was waived. 601 nodules were treated from May 2009 to December 2014 at eight centres, 449 (309 females, age 57 ± 14 years) with LA and 152 (107 females, age 57 ± 14 years) with RFA. A matched cohort composed of 138 patients from each group was selected after adjustment with propensity score matching. Factors influencing volume reduction at 6 and 12 months and complications were evaluated. Results: No significant differences were observed in the baseline characteristics between groups after propensity score matching adjustment. Mean nodule reduction at 6 and 12 months was −67 ± 19% vs. −57 ± 21% (p < 0.001) − 70 ± 19% vs. −62 ± 22% (p = 0.001) in LA group and in RFA group, respectively. Nodules with volume >30 mL had significantly higher percentage volume reduction at 6 and 12 months (−69 ± 19 vs. −50 ± 21, p = 0.001) and (−73 ± 18 vs. −54 ± 23 8, p = 0.001) in the LA group than in the RFA group, respectively. In both groups, operator’s skills affected the results. Major complications occurred in 4 cases in each group (p = 0.116) Conclusions: LA and RFA showed nearly similar outcome but LA was slightly more effective than RFA in large nodules. Operator’s skills could be crucial in determining the extent of nodule volume reduction regardless of the used technique.
Lingua originaleEnglish
pagine (da-a)911-919
Numero di pagine9
RivistaInternational Journal of Hyperthermia
Volume33
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Benign thyroid nodule
  • Cancer Research
  • Physiology
  • Physiology (medical)
  • laser ablation
  • minimally invasive treatments
  • percutaneous thermal ablation
  • radiofrequency ablation

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