TY - JOUR
T1 - A comparison of laser with radiofrequency ablation for the treatment of benign thyroid nodules: a propensity score matching analysis
AU - Pacella, Claudio Maurizio
AU - Mauri, Giovanni
AU - Cesareo, Roberto
AU - Paqualini, Valerio
AU - Cianni, Roberto
AU - De Feo, Pierpaolo
AU - Gambelunghe, Giovanni
AU - Raggiunti, Bruno
AU - Tina, Doris
AU - Deandrea, Maurilio
AU - Limone, Pier Paolo
AU - Mormile, Alberto
AU - Giusti, Massimo
AU - Oddo, Silvia
AU - Achille, Gaetano
AU - Di Stasio, Enrico
AU - Misischi, Irene
AU - Papini, Enrico
PY - 2017
Y1 - 2017
N2 - Purpose: To compare technique efficacy and safety of laser ablation (LA) and radiofrequency ablation (RFA) in treatment of benign thyroid nodules. Materials and methods: Institutional review board approval was obtained, and patients’ consent was waived. 601 nodules were treated from May 2009 to December 2014 at eight centres, 449 (309 females, age 57 ± 14 years) with LA and 152 (107 females, age 57 ± 14 years) with RFA. A matched cohort composed of 138 patients from each group was selected after adjustment with propensity score matching. Factors influencing volume reduction at 6 and 12 months and complications were evaluated. Results: No significant differences were observed in the baseline characteristics between groups after propensity score matching adjustment. Mean nodule reduction at 6 and 12 months was −67 ± 19% vs. −57 ± 21% (p < 0.001) − 70 ± 19% vs. −62 ± 22% (p = 0.001) in LA group and in RFA group, respectively. Nodules with volume >30 mL had significantly higher percentage volume reduction at 6 and 12 months (−69 ± 19 vs. −50 ± 21, p = 0.001) and (−73 ± 18 vs. −54 ± 23 8, p = 0.001) in the LA group than in the RFA group, respectively. In both groups, operator’s skills affected the results. Major complications occurred in 4 cases in each group (p = 0.116) Conclusions: LA and RFA showed nearly similar outcome but LA was slightly more effective than RFA in large nodules. Operator’s skills could be crucial in determining the extent of nodule volume reduction regardless of the used technique.
AB - Purpose: To compare technique efficacy and safety of laser ablation (LA) and radiofrequency ablation (RFA) in treatment of benign thyroid nodules. Materials and methods: Institutional review board approval was obtained, and patients’ consent was waived. 601 nodules were treated from May 2009 to December 2014 at eight centres, 449 (309 females, age 57 ± 14 years) with LA and 152 (107 females, age 57 ± 14 years) with RFA. A matched cohort composed of 138 patients from each group was selected after adjustment with propensity score matching. Factors influencing volume reduction at 6 and 12 months and complications were evaluated. Results: No significant differences were observed in the baseline characteristics between groups after propensity score matching adjustment. Mean nodule reduction at 6 and 12 months was −67 ± 19% vs. −57 ± 21% (p < 0.001) − 70 ± 19% vs. −62 ± 22% (p = 0.001) in LA group and in RFA group, respectively. Nodules with volume >30 mL had significantly higher percentage volume reduction at 6 and 12 months (−69 ± 19 vs. −50 ± 21, p = 0.001) and (−73 ± 18 vs. −54 ± 23 8, p = 0.001) in the LA group than in the RFA group, respectively. In both groups, operator’s skills affected the results. Major complications occurred in 4 cases in each group (p = 0.116) Conclusions: LA and RFA showed nearly similar outcome but LA was slightly more effective than RFA in large nodules. Operator’s skills could be crucial in determining the extent of nodule volume reduction regardless of the used technique.
KW - Benign thyroid nodule
KW - Cancer Research
KW - Physiology
KW - Physiology (medical)
KW - laser ablation
KW - minimally invasive treatments
KW - percutaneous thermal ablation
KW - radiofrequency ablation
KW - Benign thyroid nodule
KW - Cancer Research
KW - Physiology
KW - Physiology (medical)
KW - laser ablation
KW - minimally invasive treatments
KW - percutaneous thermal ablation
KW - radiofrequency ablation
UR - http://hdl.handle.net/10807/121754
U2 - 10.1080/02656736.2017.1332395
DO - 10.1080/02656736.2017.1332395
M3 - Article
SN - 0265-6736
VL - 33
SP - 911
EP - 919
JO - International Journal of Hyperthermia
JF - International Journal of Hyperthermia
ER -