A cluster of Geotrichum clavatum (Saprochaete clavata) infection in haematological patients: a first Italian report and review of literature

Maurizio Sanguinetti, Livio Pagano, Maria Ilaria Del Principe, Loredana Sarmati, Mariagiovanna Cefalo, Carla Fontana, Giovanna De Santis, Francesco Buccisano, Luca Maurillo, Eleonora De Bellis, Massimiliano Postorino, Giuseppe Sconocchia, Giovanni Del Poeta, Sergio Amadori, Adriano Venditti

Risultato della ricerca: Contributo in rivistaArticolo in rivista

22 Citazioni (Scopus)

Abstract

Invasive fungal infections, usually Aspergillus and Candida, represent a major cause of morbidity and mortality in patients with malignant haematological diseases, but in the last years rare fungal infections have more frequently been reported. Here, we report the clinical history of three patients affected with haematological malignancies who developed an infection caused by Geotrichum (G.) clavatum. Two out of three patients were affected by acute myeloid leukaemia (AML), and one by mantle cell lymphoma (MCL). All patients received cytarabine-based chemotherapeutic regimens and developed G. clavatum infection within 3 weeks from therapy initiation. In all cases, G. clavatum was isolated from central venous catheter and peripheral blood cultures. In vitro susceptibility test confirmed an intrinsic resistance to echinocandins and, in all cases, visceral localisations (spleen, liver and lung) were documented by total body computed tomography (CT) scan. A prolonged antifungal therapy with high doses liposomal amphotericin-B was necessary to obtain fever resolution. Only the patient with MCL died while the other two AML recovered, and one of them after received an allogeneic stem cell transplantation. We consecutively reviewed all published cases of infection caused by G. clavatum. Our experience and literature review indicate that G. clavatum can cause invasive infection in haematological patients, mainly in those with acute leukaemia.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaMycoses
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • (1→3)-β-d-glucan
  • Geotrichum clavatum
  • acute myeloid leukaemia
  • emerging yeast infections
  • fungaemia
  • liposomal amphotericin-B
  • susceptibility tests

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