TY - JOUR
T1 - A case-control study on the effect of Apolipoprotein E genotypes on gastric cancer risk and progression
AU - De Feo, Emma
AU - Simone, Benedetto
AU - Persiani, Roberto
AU - Cananzi, Ferdinando Carlo Maria
AU - Biondi, Alberto
AU - Arzani, Dario
AU - Amore, Rosarita
AU - D'Ugo, Domenico
AU - Ricciardi, Walter
AU - Boccia, Stefania
PY - 2012
Y1 - 2012
N2 - Background: Apolipoprotein E (ApoE) is a multifunctional protein playing both a key role in the metabolism of cholesterol and triglycerides, and in tissue repair and inflammation. The ApoE gene (19q13.2) has three major isoforms encoded by epsilon 2, epsilon 3 and epsilon 4 alleles with the epsilon 4 allele associated with hypercholesterolemia and the epsilon 2 allele with the opposite effect. An inverse relationship between cholesterol levels and gastric cancer (GC) has been previously reported, although the relationship between apoE genotypes and GC has not been explored so far. \r\n\r\nMethods: One hundred and fifty-six gastric cancer cases and 444 hospital controls were genotyped for apoE polymorphism (epsilon 2, epsilon 3, epsilon 4 alleles). The relationship between GC and putative risk factors was measured using the adjusted odds ratios (ORs) and their 95% confidence intervals (CIs) from logistic regression analysis. A gene-environment interaction analysis was performed. The effect of the apoE genotypes on survival from GC was explored by a Kaplan-Meier analysis and Cox proportional hazard regression model. \r\n\r\nResults: Subjects carrying at least one apoE epsilon 2 allele have a significant 60% decrease of GC risk (OR=0.40, 95% CI: 0.19-0.84) compared with epsilon 3 homozygotes. No significant interaction emerged between the epsilon 4 or epsilon 2 allele and environmental exposures, nor epsilon 2 or epsilon 4 alleles affected the median survival times, even after correcting for age, gender and stadium. \r\n\r\nConclusions: Our study reports for the first time a protective effect of the epsilon 2 allele against GC, that might be partly attributed to the higher antioxidant properties of epsilon 2 compared with the epsilon 3 or epsilon 4 alleles. Given the study's sample size, further studies are required to confirm our findings.
AB - Background: Apolipoprotein E (ApoE) is a multifunctional protein playing both a key role in the metabolism of cholesterol and triglycerides, and in tissue repair and inflammation. The ApoE gene (19q13.2) has three major isoforms encoded by epsilon 2, epsilon 3 and epsilon 4 alleles with the epsilon 4 allele associated with hypercholesterolemia and the epsilon 2 allele with the opposite effect. An inverse relationship between cholesterol levels and gastric cancer (GC) has been previously reported, although the relationship between apoE genotypes and GC has not been explored so far. \r\n\r\nMethods: One hundred and fifty-six gastric cancer cases and 444 hospital controls were genotyped for apoE polymorphism (epsilon 2, epsilon 3, epsilon 4 alleles). The relationship between GC and putative risk factors was measured using the adjusted odds ratios (ORs) and their 95% confidence intervals (CIs) from logistic regression analysis. A gene-environment interaction analysis was performed. The effect of the apoE genotypes on survival from GC was explored by a Kaplan-Meier analysis and Cox proportional hazard regression model. \r\n\r\nResults: Subjects carrying at least one apoE epsilon 2 allele have a significant 60% decrease of GC risk (OR=0.40, 95% CI: 0.19-0.84) compared with epsilon 3 homozygotes. No significant interaction emerged between the epsilon 4 or epsilon 2 allele and environmental exposures, nor epsilon 2 or epsilon 4 alleles affected the median survival times, even after correcting for age, gender and stadium. \r\n\r\nConclusions: Our study reports for the first time a protective effect of the epsilon 2 allele against GC, that might be partly attributed to the higher antioxidant properties of epsilon 2 compared with the epsilon 3 or epsilon 4 alleles. Given the study's sample size, further studies are required to confirm our findings.
KW - Apolipoprotein E
KW - Gene-environment interaction
KW - Genetic epidemiology
KW - case-control study
KW - Apolipoprotein E
KW - Gene-environment interaction
KW - Genetic epidemiology
KW - case-control study
UR - https://publicatt.unicatt.it/handle/10807/39953
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84867740613&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84867740613&origin=inward
U2 - 10.1186/1471-2407-12-494
DO - 10.1186/1471-2407-12-494
M3 - Article
SN - 1471-2407
VL - 12
SP - 494
EP - 494
JO - BMC Cancer
JF - BMC Cancer
IS - 1
ER -