68Ga-DOTATOC PET/CT in Pleural Solitary Fibrous Tumors

Filippo Lococo; Vittoria Rufini; Angelina Filice; Massimiliano Paci; Guido Rindi

doi:10.1097/RLU.0000000000003570

68Ga-DOTATOC PET/CT in Pleural Solitary Fibrous Tumors

Filippo Lococo
, Vittoria Rufini^*
, Angelina Filice
, Massimiliano Paci
, Guido Rindi

^*Autore corrispondente per questo lavoro

Units of Nuclear Medicine
Azienda Ospedaliera Santa Maria Nuova di Reggio Emilia

Risultato della ricerca: Contributo in rivista › Articolo

Abstract

ABSTRACT: Solitary fibrous tumor of the pleura (SFTP) is a rare mesenchymal neoplasm. Preoperative diagnosis is usually difficult and based on radiological findings only. We report the imaging results observed in 5 patients with SFTP (2 malignant) obtained by 68Ga-DOTATOC PET/CT. At qualitative analysis, all tumors showed uptake of 68Ga-DOTATOC. Mean tumor SUVmax was 9.9 ± 5.7. The expression of SST2 (somatostatin receptors subtype 2) was confirmed by immunohistochemistry in 2 tumor samples, and by gene amplification of SST2 mRNA in all cases. These data suggest a diagnostic role of radioreceptor PET/CT in SFTP, and open novel potential treatment options in unresectable/metastatic disease.

Lingua originale	Inglese
pagine (da-a)	e336-e338
Rivista	Clinical Nuclear Medicine
Volume	Publish Ahead of Print
Numero di pubblicazione	1
DOI	https://doi.org/10.1097/RLU.0000000000003570
Stato di pubblicazione	Pubblicato - 2021

All Science Journal Classification (ASJC) codes

Radiologia, Medicina Nucleare e Diagnostica per Immagini

Keywords

solitary fibrous tumor

Accesso al documento

10.1097/RLU.0000000000003570

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abstract = "ABSTRACT: Solitary fibrous tumor of the pleura (SFTP) is a rare mesenchymal neoplasm. Preoperative diagnosis is usually difficult and based on radiological findings only. We report the imaging results observed in 5 patients with SFTP (2 malignant) obtained by 68Ga-DOTATOC PET/CT. At qualitative analysis, all tumors showed uptake of 68Ga-DOTATOC. Mean tumor SUVmax was 9.9 ± 5.7. The expression of SST2 (somatostatin receptors subtype 2) was confirmed by immunohistochemistry in 2 tumor samples, and by gene amplification of SST2 mRNA in all cases. These data suggest a diagnostic role of radioreceptor PET/CT in SFTP, and open novel potential treatment options in unresectable/metastatic disease.",

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AU - Lococo, Filippo

AU - Rufini, Vittoria

AU - Filice, Angelina

AU - Paci, Massimiliano

AU - Rindi, Guido

PY - 2021

Y1 - 2021

N2 - ABSTRACT: Solitary fibrous tumor of the pleura (SFTP) is a rare mesenchymal neoplasm. Preoperative diagnosis is usually difficult and based on radiological findings only. We report the imaging results observed in 5 patients with SFTP (2 malignant) obtained by 68Ga-DOTATOC PET/CT. At qualitative analysis, all tumors showed uptake of 68Ga-DOTATOC. Mean tumor SUVmax was 9.9 ± 5.7. The expression of SST2 (somatostatin receptors subtype 2) was confirmed by immunohistochemistry in 2 tumor samples, and by gene amplification of SST2 mRNA in all cases. These data suggest a diagnostic role of radioreceptor PET/CT in SFTP, and open novel potential treatment options in unresectable/metastatic disease.

AB - ABSTRACT: Solitary fibrous tumor of the pleura (SFTP) is a rare mesenchymal neoplasm. Preoperative diagnosis is usually difficult and based on radiological findings only. We report the imaging results observed in 5 patients with SFTP (2 malignant) obtained by 68Ga-DOTATOC PET/CT. At qualitative analysis, all tumors showed uptake of 68Ga-DOTATOC. Mean tumor SUVmax was 9.9 ± 5.7. The expression of SST2 (somatostatin receptors subtype 2) was confirmed by immunohistochemistry in 2 tumor samples, and by gene amplification of SST2 mRNA in all cases. These data suggest a diagnostic role of radioreceptor PET/CT in SFTP, and open novel potential treatment options in unresectable/metastatic disease.

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68Ga-DOTATOC PET/CT in Pleural Solitary Fibrous Tumors

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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