5-year-old boy with a clival mass.

Gianpiero Tamburrini, Benedetta Ludovica Pettorini, Federica Novegno, Alessandro Cianfoni, Luca Massimi, Pasquale De Bonis, Giuseppe Esposito, Massimo Caldarelli, Concezio Di Rocco, Libero Lauriola, Felice Giangaspero

Risultato della ricerca: Contributo in rivistaArticolo in rivista

6 Citazioni (Scopus)

Abstract

Epithelioid sarcoma is a rare tumor originating from mesenchymal cells, usually involving the extremities of young adults and is found only sporadically in the head and neck region. Only one case involving the central nervous system has been described so far. We report a 5 year-old boy with a large solid, osteolytic lesion of the clivus with a wide soft tissue component expanding into the intracranial compartment and obliterating the prepontine cistern. Histopathological examination revealed epithelioid neoplastic cells with abundant eosinophilic cytoplasm, rounded nuclei and prominent nucleoli. Areas of geographic necrosis and numerous mitoses were present. Neoplastic cells immunostained for vimentin, cytokeratin, and epithelial membrane antigen (EMA). No immunostaining was observed for glial fibrillary associated protein (GFAP), S-100, PLAP, α-fetoprotein, CD 117, CD 34, CD 31, BAF-47 (INI1). The Ki67 proliferation index exceeded 40%. These histological findings favor a diagnosis of epithelioid sarcoma. This report adds epithelioid sarcoma to the differential diagnosis of both clival tumors and pediatric skull base tumors.
Lingua originaleEnglish
pagine (da-a)523-526
Numero di pagine4
RivistaBrain Pathology
Volume19
Stato di pubblicazionePubblicato - 2009

Keywords

  • brain

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