38. Clinical and electrophysiological measures in the diagnosis of disturb of consciousness

Michela Balconi, Maria Elide Vanutelli, Roberta Arangio

Risultato della ricerca: Contributo in rivistaContributo a convegnopeer review

Abstract

The present research was intended to verify the relationship between traditional clinical measures (Coma Near Coma and Disability Rating Scales; CNC, DRS) to assess residual cognitive abilities in Disturb Of Consciousness (DOC) and N400 ERP index, in response to a semantic associative task. The sample was made up of 18 patients, sub-divided into two subgroups according to the clinical scorings: Vegetative State (VS) and Minimally Conscious State (MCS). They were submitted to a semantic associative auditory task that included 60 congruous (related final words) or incongruous (unrelated final words) word sequences. Results showed that all patients exhibited a N400 deflection over the fronto-central areas similar to that of healthy subjects. However this deflection was delayed in latency for incongruous word sequences. This effect was greater for VS in comparison with MCS patients, and significantly correlated with the behavioral scales, so that an increased impairment was related to a longer latency for incongruous conditions. The presence of N400 index was a strong evidence of preserved higher cognitive functions in DOC patients. However, N400 was differently modulated for VS and MCS patients. Electrophysiological measures could prevent misdiagnosis and lead to correctly classify different consciousness profiles.
Lingua originaleEnglish
pagine (da-a)e9-e10
Numero di pagine2
RivistaClinical Neurophysiology
Volume126
DOI
Stato di pubblicazionePubblicato - 2014
Evento59th National Congress of SINC, Società Italiana di Neurofisiologia Clinica - Milano
Durata: 14 mag 201417 mag 2014

Keywords

  • Assessment
  • Disorders of consciousness

Fingerprint Entra nei temi di ricerca di '38. Clinical and electrophysiological measures in the diagnosis of disturb of consciousness'. Insieme formano una fingerprint unica.

Cita questo