2019 update to: Management of hyperglycemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Geltrude Mingrone, John B. Buse, Deborah J. Wexler, Apostolos Tsapas, Peter Rossing, Chantal Mathieu, David A. D'Alessio, Melanie J. Davies

Risultato della ricerca: Contributo in rivistaArticolo in rivista

204 Citazioni (Scopus)

Abstract

The American Diabetes Association and the European Association for the Study of Diabetes have briefly updated their 2018 recommendations on management of hyperglycemia, based on important research findings from large cardiovascular outcomes trials published in 2019. Important changes include: 1) the decision to treat high-risk individuals witha glucagon-like peptide1 (GLP-1) receptor agonist or sodium-glucose cotransporter 2 (SGLT2) inhibitor to reduce major adverse cardiovascular events (MACE), hospitalization for heart failure (hHF), cardiovascular death, or chronic kidney disease (CKD) progression should be considered independently of baseline HbA1c or individualized HbA1c target; 2) GLP-1 receptor agonists can alsobeconsidered in patients with type 2 diabetes without established cardiovascular disease (CVD) but withthe presence of specific indicators of high risk; and 3)SGLT2 inhibitors are recommended in patients with type 2 diabetes and heart failure, particularly those with heart failure with reduced ejection fraction, to reduce hHF, MACE, and CVD death, as well as in patients with type 2 diabetes with CKD (estimated glomerular filtration rate 30 to ≤60 mL min-1 [1.73 m]2 or urinary albumin-to-creatinine ratio >30 mg/g, particularly >300 mg/g) to prevent the progression of CKD, hHF, MACE, and cardiovascular death.
Lingua originaleEnglish
pagine (da-a)487-493
Numero di pagine7
RivistaDiabetes Care
Volume43
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • Cardiovascular Diseases
  • Consensus
  • Diabetes Complications
  • Diabetes Mellitus, Type 2
  • Europe
  • History, 21st Century
  • Humans
  • Hyperglycemia
  • Hypoglycemic Agents
  • Male
  • Renal Insufficiency, Chronic
  • Societies, Medical
  • Sodium-Glucose Transporter 2 Inhibitors
  • United States

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