2012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B: estimates from a European network of hospitals

Katleen De Gaetano Donati, Roberto Cauda, Rosaria Santangelo, Giovanni Fichera, M. Rondy, O. Launay, J. Puig-Barberà, G. Gefenaite, J. Castilla, F. Galtier, E. Hak, M. Guevara, S. Costanzo, A. Moren, Nezha Lenzi, Zineb Lesieur, Isabelle Bonmarin, Xavier Duval, Yolande Costa, Annuxcy KanagaratnamYazdan Yazdapanah, Marion Caseris, Nathalie Dournon, Thomas Papo, Antoine Dossier, Hakim Bécheur, Anne-Laure Pelletier, Hervé Mal, Armelle Marceau, Michel Aubier, Raphaêl Bories, Enrique Casalino, Christophe Choquet, Nadhira Houhou, Pierre Loulergue, Reem Kanaan, Florence Dumas, Déborah Postil, Sébastien Alcoléa, Sylvie Rogez, Philippe Vanhaems, Corinne Régis, Corinne Merle, Vincent Foulongne, Marine Ray, Véronique Maugueret-Doublet, Arnaud Bourdin, Liliane Landreau, Amadou Konaté, Philippe Corne, Mustapha Sebbane, Kada Klouche, Marie-Suzanne Léglise, Martine Valette, Bruno Lina, Fabrice Carrat, Frédéric Chau, Javier Díez-Domingo, Begoña Escribano-López, Alberto Arnedo-Pena, Montserrat Ruiz-García, Miguel Tortajada-Girbés, Consuelo Carratalá Munuera, Julio Barrenengoa Sañudo, Rosa Larrea-González, Vicente Gil-Guillén, German Schwarz-Chavarri, Janette Rahamat-Langendoen, Hubert Niesters, Arvydas Ambrozaitis, Ligita Jancoriene, Aukse Mickiene, Monika Kuliese, Daiva Velyvyte, Ronald P. Stolk, Kestutis Zagminas, Carmen Ezpeleta, Judith Chamorro, Pilar Artajo, Francisco Lameiro, Ana Navascués, Maite Ortega, Montse Torres, José Javier García Irure, Fátima Irisarri, Manuel García Cenoz, Iván Martínez-Baz, Francesco Perlasca, Marianna Dara, Licia Iacoviello, Marco Olivieri

Risultato della ricerca: Contributo in rivistaArticolo in rivista

22 Citazioni (Scopus)

Abstract

While influenza vaccines aim to decrease the incidence of severe influenza among high-risk groups, evidence of influenza vaccine effectiveness (IVE) among the influenza vaccine target population is sparse. We conducted a multicentre test-negative case–control study to estimate IVE against hospitalised laboratoryconfirmed influenza in the target population in 18 hospitals in France, Italy, Lithuania and the Navarre and Valencia regions in Spain. All hospitalised patients aged ≥18 years, belonging to the target population presenting with influenza-like illness symptom onset within seven days were swabbed. Patients positive by reverse transcription polymerase chain reaction for influenza virus were cases and those negative were controls. Using logistic regression, we calculated IVE for each influenza virus subtype and adjusted it for month of symptom onset, study site, age and chronic conditions. Of the 1,972 patients included, 116 were positive for influenza A(H1N1)pdm09, 58 for A(H3N2) and 232 for influenza B. Adjusted IVE was 21.3% (95% confidence interval (CI): -25.2 to 50.6; n=1,628), 61.8% (95% CI: 26.8 to 80.0; n=557) and 43.1% (95% CI: 21.2 to 58.9; n=1,526) against influenza A(H1N1) pdm09, A(H3N2) and B respectively. Our results suggest that the 2012/13 IVE was moderate against influenza A(H3N2) and B and low against influenza A(H1N1) pdm09.
Lingua originaleEnglish
pagine (da-a)9-20
Numero di pagine12
RivistaEurosurveillance
Volume20
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Europe
  • European Union
  • Female
  • Hospitalization
  • Humans
  • Influenza A Virus, H1N1 Subtype
  • Influenza A Virus, H3N2 Subtype
  • Influenza B virus
  • Influenza Vaccines
  • Influenza, Human
  • Logistic Models
  • Male
  • Middle Aged
  • Seasons
  • Sentinel Surveillance
  • Treatment Outcome
  • Vaccination
  • Young Adult

Fingerprint Entra nei temi di ricerca di '2012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B: estimates from a European network of hospitals'. Insieme formano una fingerprint unica.

Cita questo