2012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B: estimates from a European network of hospitals

M. Rondy, O. Launay, J. Puig-Barbera, G. Gefenaite, J. Castilla, Donati K. de Gaetano, F. Galtier, E. Hak, M. Guevara, S. Costanzo, A. Moren, N. Lenzi, Z. Lesieur, I. Bonmarin, X. Duval, Y. Costa, A. Kanagaratnam, Y. Yazdapanah, M. Caseris, N. DournonT. Papo, A. Dossier, H. Becheur, Pelletier A. -L., H. Mal, A. Marceau, M. Aubier, R. Bories, E. Casalino, C. Choquet, N. Houhou, P. Loulergue, R. Kanaan, F. Dumas, D. Postil, S. Alcolea, S. Rogez, P. Vanhaems, C. Regis, C. Merle, V. Foulongne, M. Ray, V. Maugueret-Doublet, A. Bourdin, L. Landreau, A. Konate, P. Corne, M. Sebbane, K. Klouche, Leglise M. -S., M. Valette, B. Lina, F. Carrat, F. Chau, J. Diez-Domingo, B. Escribano-Lopez, A. Arnedo-Pena, M. Ruiz-Garcia, M. Tortajada-Girbes, C. C. Munuera, J. B. Sanudo, R. Larrea-Gonzalez, V. Gil-Guillen, G. Schwarz-Chavarri, J. Rahamat-Langendoen, H. Niesters, A. Ambrozaitis, L. Jancoriene, A. Mickiene, M. Kuliese, D. Velyvyte, R. P. Stolk, K. Zagminas, C. Ezpeleta, J. Chamorro, P. Artajo, F. Lameiro, A. Navascues, M. Ortega, M. Torres, J. J. G. Irure, F. Irisarri, M. G. Cenoz, I. Martinez-Baz, R. Cauda, C. Donato, Rosaria Santangelo, F. Perlasca, G. Fichera, M. Dara, L. Iacoviello, M. Olivieri

Risultato della ricerca: Contributo in rivistaArticolo in rivista

22 Citazioni (Scopus)

Abstract

While influenza vaccines aim to decrease the incidence of severe influenza among high-risk groups, evidence of influenza vaccine effectiveness (IVE) among the influenza vaccine target population is sparse. We conducted a multicentre test-negative case–control study to estimate IVE against hospitalised laboratoryconfirmed influenza in the target population in 18 hospitals in France, Italy, Lithuania and the Navarre and Valencia regions in Spain. All hospitalised patients aged ≥18 years, belonging to the target population presenting with influenza-like illness symptom onset within seven days were swabbed. Patients positive by reverse transcription polymerase chain reaction for influenza virus were cases and those negative were controls. Using logistic regression, we calculated IVE for each influenza virus subtype and adjusted it for month of symptom onset, study site, age and chronic conditions. Of the 1,972 patients included, 116 were positive for influenza A(H1N1)pdm09, 58 for A(H3N2) and 232 for influenza B. Adjusted IVE was 21.3% (95% confidence interval (CI): -25.2 to 50.6; n=1,628), 61.8% (95% CI: 26.8 to 80.0; n=557) and 43.1% (95% CI: 21.2 to 58.9; n=1,526) against influenza A(H1N1) pdm09, A(H3N2) and B respectively. Our results suggest that the 2012/13 IVE was moderate against influenza A(H3N2) and B and low against influenza A(H1N1) pdm09.
Lingua originaleEnglish
pagine (da-a)9-20
Numero di pagine12
RivistaEurosurveillance
Volume20
Numero di pubblicazione2
DOI
Stato di pubblicazionePubblicato - 2015

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.2700.2713???
  • ???subjectarea.asjc.2700.2739???
  • ???subjectarea.asjc.2400.2406???

Keywords

  • 80 and over
  • Adolescent
  • Adult
  • Aged
  • Case-Control Studies
  • Europe
  • European Union
  • Female
  • H1N1 Subtype
  • H3N2 Subtype
  • Hospitalization
  • Human
  • Humans
  • Influenza
  • Influenza A Virus
  • Influenza B virus
  • Influenza Vaccines
  • Logistic Models
  • Male
  • Middle Aged
  • Seasons
  • Sentinel Surveillance
  • Treatment Outcome
  • Vaccination
  • Young Adult

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