2012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B: estimates from a European network of hospitals

Katleen De Gaetano Donati; Roberto Cauda; Rosaria Santangelo; Giovanni Fichera; M. Rondy; O. Launay; J. Puig-Barberà; G. Gefenaite; J. Castilla; F. Galtier; E. Hak; M. Guevara; S. Costanzo; A. Moren; Nezha Lenzi; Zineb Lesieur; Isabelle Bonmarin; Xavier Duval; Yolande Costa; Annuxcy Kanagaratnam; Yazdan Yazdapanah; Marion Caseris; Nathalie Dournon; Thomas Papo; Antoine Dossier; Hakim Bécheur; Anne-Laure Pelletier; Hervé Mal; Armelle Marceau; Michel Aubier; Raphaêl Bories; Enrique Casalino; Christophe Choquet; Nadhira Houhou; Pierre Loulergue; Reem Kanaan; Florence Dumas; Déborah Postil; Sébastien Alcoléa; Sylvie Rogez; Philippe Vanhaems; Corinne Régis; Corinne Merle; Vincent Foulongne; Marine Ray; Véronique Maugueret-Doublet; Arnaud Bourdin; Liliane Landreau; Amadou Konaté; Philippe Corne; Mustapha Sebbane; Kada Klouche; Marie-Suzanne Léglise; Martine Valette; Bruno Lina; Fabrice Carrat; Frédéric Chau; Javier Díez-Domingo; Begoña Escribano-López; Alberto Arnedo-Pena; Montserrat Ruiz-García; Miguel Tortajada-Girbés; Consuelo Carratalá Munuera; Julio Barrenengoa Sañudo; Rosa Larrea-González; Vicente Gil-Guillén; German Schwarz-Chavarri; Janette Rahamat-Langendoen; Hubert Niesters; Arvydas Ambrozaitis; Ligita Jancoriene; Aukse Mickiene; Monika Kuliese; Daiva Velyvyte; Ronald P. Stolk; Kestutis Zagminas; Carmen Ezpeleta; Judith Chamorro; Pilar Artajo; Francisco Lameiro; Ana Navascués; Maite Ortega; Montse Torres; José Javier García Irure; Fátima Irisarri; Manuel García Cenoz; Iván Martínez-Baz; Francesco Perlasca; Marianna Dara; Licia Iacoviello; Marco Olivieri

doi:10.2807/1560-7917.ES2015.20.2.21011

2012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B: estimates from a European network of hospitals

Katleen De Gaetano Donati, Roberto Cauda, Rosaria Santangelo, Giovanni Fichera, M. Rondy, O. Launay, J. Puig-Barberà, G. Gefenaite, J. Castilla, F. Galtier, E. Hak, M. Guevara, S. Costanzo, A. Moren, Nezha Lenzi, Zineb Lesieur, Isabelle Bonmarin, Xavier Duval, Yolande Costa, Annuxcy KanagaratnamYazdan Yazdapanah, Marion Caseris, Nathalie Dournon, Thomas Papo, Antoine Dossier, Hakim Bécheur, Anne-Laure Pelletier, Hervé Mal, Armelle Marceau, Michel Aubier, Raphaêl Bories, Enrique Casalino, Christophe Choquet, Nadhira Houhou, Pierre Loulergue, Reem Kanaan, Florence Dumas, Déborah Postil, Sébastien Alcoléa, Sylvie Rogez, Philippe Vanhaems, Corinne Régis, Corinne Merle, Vincent Foulongne, Marine Ray, Véronique Maugueret-Doublet, Arnaud Bourdin, Liliane Landreau, Amadou Konaté, Philippe Corne, Mustapha Sebbane, Kada Klouche, Marie-Suzanne Léglise, Martine Valette, Bruno Lina, Fabrice Carrat, Frédéric Chau, Javier Díez-Domingo, Begoña Escribano-López, Alberto Arnedo-Pena, Montserrat Ruiz-García, Miguel Tortajada-Girbés, Consuelo Carratalá Munuera, Julio Barrenengoa Sañudo, Rosa Larrea-González, Vicente Gil-Guillén, German Schwarz-Chavarri, Janette Rahamat-Langendoen, Hubert Niesters, Arvydas Ambrozaitis, Ligita Jancoriene, Aukse Mickiene, Monika Kuliese, Daiva Velyvyte, Ronald P. Stolk, Kestutis Zagminas, Carmen Ezpeleta, Judith Chamorro, Pilar Artajo, Francisco Lameiro, Ana Navascués, Maite Ortega, Montse Torres, José Javier García Irure, Fátima Irisarri, Manuel García Cenoz, Iván Martínez-Baz, Francesco Perlasca, Marianna Dara, Licia Iacoviello, Marco Olivieri

Risultato della ricerca: Contributo in rivista › Articolo in rivista

22 Citazioni (Scopus)

Abstract

While influenza vaccines aim to decrease the incidence of severe influenza among high-risk groups, evidence of influenza vaccine effectiveness (IVE) among the influenza vaccine target population is sparse. We conducted a multicentre test-negative case–control study to estimate IVE against hospitalised laboratoryconfirmed influenza in the target population in 18 hospitals in France, Italy, Lithuania and the Navarre and Valencia regions in Spain. All hospitalised patients aged ≥18 years, belonging to the target population presenting with influenza-like illness symptom onset within seven days were swabbed. Patients positive by reverse transcription polymerase chain reaction for influenza virus were cases and those negative were controls. Using logistic regression, we calculated IVE for each influenza virus subtype and adjusted it for month of symptom onset, study site, age and chronic conditions. Of the 1,972 patients included, 116 were positive for influenza A(H1N1)pdm09, 58 for A(H3N2) and 232 for influenza B. Adjusted IVE was 21.3% (95% confidence interval (CI): -25.2 to 50.6; n=1,628), 61.8% (95% CI: 26.8 to 80.0; n=557) and 43.1% (95% CI: 21.2 to 58.9; n=1,526) against influenza A(H1N1) pdm09, A(H3N2) and B respectively. Our results suggest that the 2012/13 IVE was moderate against influenza A(H3N2) and B and low against influenza A(H1N1) pdm09.

Lingua originale	English
pagine (da-a)	9-20
Numero di pagine	12
Rivista	Eurosurveillance
Volume	20
DOI	https://doi.org/10.2807/1560-7917.ES2015.20.2.21011
Stato di pubblicazione	Pubblicato - 2015

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Case-Control Studies
Europe
European Union
Female
Hospitalization
Humans
Influenza A Virus, H1N1 Subtype
Influenza A Virus, H3N2 Subtype
Influenza B virus
Influenza Vaccines
Influenza, Human
Logistic Models
Male
Middle Aged
Seasons
Sentinel Surveillance
Treatment Outcome
Vaccination
Young Adult

Accesso al documento

10.2807/1560-7917.ES2015.20.2.21011

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De Gaetano Donati, K., Cauda, R., Santangelo, R., Fichera, G., Rondy, M., Launay, O., Puig-Barberà, J., Gefenaite, G., Castilla, J., Galtier, F., Hak, E., Guevara, M., Costanzo, S., Moren, A., Lenzi, N., Lesieur, Z., Bonmarin, I., Duval, X., Costa, Y., ... Olivieri, M. (2015). 2012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B: estimates from a European network of hospitals. Eurosurveillance, 20, 9-20. https://doi.org/10.2807/1560-7917.ES2015.20.2.21011

De Gaetano Donati, Katleen ; Cauda, Roberto ; Santangelo, Rosaria ; Fichera, Giovanni ; Rondy, M. ; Launay, O. ; Puig-Barberà, J. ; Gefenaite, G. ; Castilla, J. ; Galtier, F. ; Hak, E. ; Guevara, M. ; Costanzo, S. ; Moren, A. ; Lenzi, Nezha ; Lesieur, Zineb ; Bonmarin, Isabelle ; Duval, Xavier ; Costa, Yolande ; Kanagaratnam, Annuxcy ; Yazdapanah, Yazdan ; Caseris, Marion ; Dournon, Nathalie ; Papo, Thomas ; Dossier, Antoine ; Bécheur, Hakim ; Pelletier, Anne-Laure ; Mal, Hervé ; Marceau, Armelle ; Aubier, Michel ; Bories, Raphaêl ; Casalino, Enrique ; Choquet, Christophe ; Houhou, Nadhira ; Loulergue, Pierre ; Kanaan, Reem ; Dumas, Florence ; Postil, Déborah ; Alcoléa, Sébastien ; Rogez, Sylvie ; Vanhaems, Philippe ; Régis, Corinne ; Merle, Corinne ; Foulongne, Vincent ; Ray, Marine ; Maugueret-Doublet, Véronique ; Bourdin, Arnaud ; Landreau, Liliane ; Konaté, Amadou ; Corne, Philippe ; Sebbane, Mustapha ; Klouche, Kada ; Léglise, Marie-Suzanne ; Valette, Martine ; Lina, Bruno ; Carrat, Fabrice ; Chau, Frédéric ; Díez-Domingo, Javier ; Escribano-López, Begoña ; Arnedo-Pena, Alberto ; Ruiz-García, Montserrat ; Tortajada-Girbés, Miguel ; Munuera, Consuelo Carratalá ; Sañudo, Julio Barrenengoa ; Larrea-González, Rosa ; Gil-Guillén, Vicente ; Schwarz-Chavarri, German ; Rahamat-Langendoen, Janette ; Niesters, Hubert ; Ambrozaitis, Arvydas ; Jancoriene, Ligita ; Mickiene, Aukse ; Kuliese, Monika ; Velyvyte, Daiva ; Stolk, Ronald P. ; Zagminas, Kestutis ; Ezpeleta, Carmen ; Chamorro, Judith ; Artajo, Pilar ; Lameiro, Francisco ; Navascués, Ana ; Ortega, Maite ; Torres, Montse ; Irure, José Javier García ; Irisarri, Fátima ; Cenoz, Manuel García ; Martínez-Baz, Iván ; Perlasca, Francesco ; Dara, Marianna ; Iacoviello, Licia ; Olivieri, Marco. / 2012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B: estimates from a European network of hospitals. In: Eurosurveillance. 2015 ; Vol. 20. pagg. 9-20.

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title = "2012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B: estimates from a European network of hospitals",

abstract = "While influenza vaccines aim to decrease the incidence of severe influenza among high-risk groups, evidence of influenza vaccine effectiveness (IVE) among the influenza vaccine target population is sparse. We conducted a multicentre test-negative case–control study to estimate IVE against hospitalised laboratoryconfirmed influenza in the target population in 18 hospitals in France, Italy, Lithuania and the Navarre and Valencia regions in Spain. All hospitalised patients aged ≥18 years, belonging to the target population presenting with influenza-like illness symptom onset within seven days were swabbed. Patients positive by reverse transcription polymerase chain reaction for influenza virus were cases and those negative were controls. Using logistic regression, we calculated IVE for each influenza virus subtype and adjusted it for month of symptom onset, study site, age and chronic conditions. Of the 1,972 patients included, 116 were positive for influenza A(H1N1)pdm09, 58 for A(H3N2) and 232 for influenza B. Adjusted IVE was 21.3% (95% confidence interval (CI): -25.2 to 50.6; n=1,628), 61.8% (95% CI: 26.8 to 80.0; n=557) and 43.1% (95% CI: 21.2 to 58.9; n=1,526) against influenza A(H1N1) pdm09, A(H3N2) and B respectively. Our results suggest that the 2012/13 IVE was moderate against influenza A(H3N2) and B and low against influenza A(H1N1) pdm09.",

keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Case-Control Studies, Europe, European Union, Female, Hospitalization, Humans, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Influenza B virus, Influenza Vaccines, Influenza, Human, Logistic Models, Male, Middle Aged, Seasons, Sentinel Surveillance, Treatment Outcome, Vaccination, Young Adult, Adolescent, Adult, Aged, Aged, 80 and over, Case-Control Studies, Europe, European Union, Female, Hospitalization, Humans, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Influenza B virus, Influenza Vaccines, Influenza, Human, Logistic Models, Male, Middle Aged, Seasons, Sentinel Surveillance, Treatment Outcome, Vaccination, Young Adult",

author = "{De Gaetano Donati}, Katleen and Roberto Cauda and Rosaria Santangelo and Giovanni Fichera and M. Rondy and O. Launay and J. Puig-Barber{\`a} and G. Gefenaite and J. Castilla and F. Galtier and E. Hak and M. Guevara and S. Costanzo and A. Moren and Nezha Lenzi and Zineb Lesieur and Isabelle Bonmarin and Xavier Duval and Yolande Costa and Annuxcy Kanagaratnam and Yazdan Yazdapanah and Marion Caseris and Nathalie Dournon and Thomas Papo and Antoine Dossier and Hakim B{\'e}cheur and Anne-Laure Pelletier and Herv{\'e} Mal and Armelle Marceau and Michel Aubier and Rapha{\^e}l Bories and Enrique Casalino and Christophe Choquet and Nadhira Houhou and Pierre Loulergue and Reem Kanaan and Florence Dumas and D{\'e}borah Postil and S{\'e}bastien Alcol{\'e}a and Sylvie Rogez and Philippe Vanhaems and Corinne R{\'e}gis and Corinne Merle and Vincent Foulongne and Marine Ray and V{\'e}ronique Maugueret-Doublet and Arnaud Bourdin and Liliane Landreau and Amadou Konat{\'e} and Philippe Corne and Mustapha Sebbane and Kada Klouche and Marie-Suzanne L{\'e}glise and Martine Valette and Bruno Lina and Fabrice Carrat and Fr{\'e}d{\'e}ric Chau and Javier D{\'i}ez-Domingo and Bego{\~n}a Escribano-L{\'o}pez and Alberto Arnedo-Pena and Montserrat Ruiz-Garc{\'i}a and Miguel Tortajada-Girb{\'e}s and Munuera, {Consuelo Carratal{\'a}} and Sa{\~n}udo, {Julio Barrenengoa} and Rosa Larrea-Gonz{\'a}lez and Vicente Gil-Guill{\'e}n and German Schwarz-Chavarri and Janette Rahamat-Langendoen and Hubert Niesters and Arvydas Ambrozaitis and Ligita Jancoriene and Aukse Mickiene and Monika Kuliese and Daiva Velyvyte and Stolk, {Ronald P.} and Kestutis Zagminas and Carmen Ezpeleta and Judith Chamorro and Pilar Artajo and Francisco Lameiro and Ana Navascu{\'e}s and Maite Ortega and Montse Torres and Irure, {Jos{\'e} Javier Garc{\'i}a} and F{\'a}tima Irisarri and Cenoz, {Manuel Garc{\'i}a} and Iv{\'a}n Mart{\'i}nez-Baz and Francesco Perlasca and Marianna Dara and Licia Iacoviello and Marco Olivieri",

year = "2015",

doi = "10.2807/1560-7917.ES2015.20.2.21011",

language = "English",

volume = "20",

pages = "9--20",

journal = "Eurosurveillance",

issn = "1560-7917",

publisher = "Centre europ{\'e}en pour la surveillance {\'e}pid{\'e}miologique du Sida",

}

De Gaetano Donati, K , Cauda, R , Santangelo, R, Fichera, G, Rondy, M, Launay, O, Puig-Barberà, J, Gefenaite, G, Castilla, J, Galtier, F, Hak, E, Guevara, M, Costanzo, S, Moren, A, Lenzi, N, Lesieur, Z, Bonmarin, I, Duval, X, Costa, Y, Kanagaratnam, A, Yazdapanah, Y, Caseris, M, Dournon, N, Papo, T, Dossier, A, Bécheur, H, Pelletier, A-L, Mal, H, Marceau, A, Aubier, M, Bories, R, Casalino, E, Choquet, C, Houhou, N, Loulergue, P, Kanaan, R, Dumas, F, Postil, D, Alcoléa, S, Rogez, S, Vanhaems, P, Régis, C, Merle, C, Foulongne, V, Ray, M, Maugueret-Doublet, V, Bourdin, A, Landreau, L, Konaté, A, Corne, P, Sebbane, M, Klouche, K, Léglise, M-S, Valette, M, Lina, B, Carrat, F, Chau, F, Díez-Domingo, J, Escribano-López, B, Arnedo-Pena, A, Ruiz-García, M, Tortajada-Girbés, M, Munuera, CC, Sañudo, JB, Larrea-González, R, Gil-Guillén, V, Schwarz-Chavarri, G, Rahamat-Langendoen, J, Niesters, H, Ambrozaitis, A, Jancoriene, L, Mickiene, A, Kuliese, M, Velyvyte, D, Stolk, RP, Zagminas, K, Ezpeleta, C, Chamorro, J, Artajo, P, Lameiro, F, Navascués, A, Ortega, M, Torres, M, Irure, JJG, Irisarri, F, Cenoz, MG, Martínez-Baz, I, Perlasca, F, Dara, M, Iacoviello, L & Olivieri, M 2015, '2012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B: estimates from a European network of hospitals', Eurosurveillance, vol. 20, pagg. 9-20. https://doi.org/10.2807/1560-7917.ES2015.20.2.21011

2012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B: estimates from a European network of hospitals. / De Gaetano Donati, Katleen ; Cauda, Roberto ; Santangelo, Rosaria; Fichera, Giovanni; Rondy, M.; Launay, O.; Puig-Barberà, J.; Gefenaite, G.; Castilla, J.; Galtier, F.; Hak, E.; Guevara, M.; Costanzo, S.; Moren, A.; Lenzi, Nezha; Lesieur, Zineb; Bonmarin, Isabelle; Duval, Xavier; Costa, Yolande; Kanagaratnam, Annuxcy; Yazdapanah, Yazdan; Caseris, Marion; Dournon, Nathalie; Papo, Thomas; Dossier, Antoine; Bécheur, Hakim; Pelletier, Anne-Laure; Mal, Hervé; Marceau, Armelle; Aubier, Michel; Bories, Raphaêl; Casalino, Enrique; Choquet, Christophe; Houhou, Nadhira; Loulergue, Pierre; Kanaan, Reem; Dumas, Florence; Postil, Déborah; Alcoléa, Sébastien; Rogez, Sylvie; Vanhaems, Philippe; Régis, Corinne; Merle, Corinne; Foulongne, Vincent; Ray, Marine; Maugueret-Doublet, Véronique; Bourdin, Arnaud; Landreau, Liliane; Konaté, Amadou; Corne, Philippe; Sebbane, Mustapha; Klouche, Kada; Léglise, Marie-Suzanne; Valette, Martine; Lina, Bruno; Carrat, Fabrice; Chau, Frédéric; Díez-Domingo, Javier; Escribano-López, Begoña; Arnedo-Pena, Alberto; Ruiz-García, Montserrat; Tortajada-Girbés, Miguel; Munuera, Consuelo Carratalá; Sañudo, Julio Barrenengoa; Larrea-González, Rosa; Gil-Guillén, Vicente; Schwarz-Chavarri, German; Rahamat-Langendoen, Janette; Niesters, Hubert; Ambrozaitis, Arvydas; Jancoriene, Ligita; Mickiene, Aukse; Kuliese, Monika; Velyvyte, Daiva; Stolk, Ronald P.; Zagminas, Kestutis; Ezpeleta, Carmen; Chamorro, Judith; Artajo, Pilar; Lameiro, Francisco; Navascués, Ana; Ortega, Maite; Torres, Montse; Irure, José Javier García; Irisarri, Fátima; Cenoz, Manuel García; Martínez-Baz, Iván; Perlasca, Francesco; Dara, Marianna; Iacoviello, Licia; Olivieri, Marco.

In: Eurosurveillance, Vol. 20, 2015, pag. 9-20.

Risultato della ricerca: Contributo in rivista › Articolo in rivista

TY - JOUR

T1 - 2012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B: estimates from a European network of hospitals

AU - De Gaetano Donati, Katleen

AU - Cauda, Roberto

AU - Santangelo, Rosaria

AU - Fichera, Giovanni

AU - Rondy, M.

AU - Launay, O.

AU - Puig-Barberà, J.

AU - Gefenaite, G.

AU - Castilla, J.

AU - Galtier, F.

AU - Hak, E.

AU - Guevara, M.

AU - Costanzo, S.

AU - Moren, A.

AU - Lenzi, Nezha

AU - Lesieur, Zineb

AU - Bonmarin, Isabelle

AU - Duval, Xavier

AU - Costa, Yolande

AU - Kanagaratnam, Annuxcy

AU - Yazdapanah, Yazdan

AU - Caseris, Marion

AU - Dournon, Nathalie

AU - Papo, Thomas

AU - Dossier, Antoine

AU - Bécheur, Hakim

AU - Pelletier, Anne-Laure

AU - Mal, Hervé

AU - Marceau, Armelle

AU - Aubier, Michel

AU - Bories, Raphaêl

AU - Casalino, Enrique

AU - Choquet, Christophe

AU - Houhou, Nadhira

AU - Loulergue, Pierre

AU - Kanaan, Reem

AU - Dumas, Florence

AU - Postil, Déborah

AU - Alcoléa, Sébastien

AU - Rogez, Sylvie

AU - Vanhaems, Philippe

AU - Régis, Corinne

AU - Merle, Corinne

AU - Foulongne, Vincent

AU - Ray, Marine

AU - Maugueret-Doublet, Véronique

AU - Bourdin, Arnaud

AU - Landreau, Liliane

AU - Konaté, Amadou

AU - Corne, Philippe

AU - Sebbane, Mustapha

AU - Klouche, Kada

AU - Léglise, Marie-Suzanne

AU - Valette, Martine

AU - Lina, Bruno

AU - Carrat, Fabrice

AU - Chau, Frédéric

AU - Díez-Domingo, Javier

AU - Escribano-López, Begoña

AU - Arnedo-Pena, Alberto

AU - Ruiz-García, Montserrat

AU - Tortajada-Girbés, Miguel

AU - Munuera, Consuelo Carratalá

AU - Sañudo, Julio Barrenengoa

AU - Larrea-González, Rosa

AU - Gil-Guillén, Vicente

AU - Schwarz-Chavarri, German

AU - Rahamat-Langendoen, Janette

AU - Niesters, Hubert

AU - Ambrozaitis, Arvydas

AU - Jancoriene, Ligita

AU - Mickiene, Aukse

AU - Kuliese, Monika

AU - Velyvyte, Daiva

AU - Stolk, Ronald P.

AU - Zagminas, Kestutis

AU - Ezpeleta, Carmen

AU - Chamorro, Judith

AU - Artajo, Pilar

AU - Lameiro, Francisco

AU - Navascués, Ana

AU - Ortega, Maite

AU - Torres, Montse

AU - Irure, José Javier García

AU - Irisarri, Fátima

AU - Cenoz, Manuel García

AU - Martínez-Baz, Iván

AU - Perlasca, Francesco

AU - Dara, Marianna

AU - Iacoviello, Licia

AU - Olivieri, Marco

PY - 2015

Y1 - 2015

N2 - While influenza vaccines aim to decrease the incidence of severe influenza among high-risk groups, evidence of influenza vaccine effectiveness (IVE) among the influenza vaccine target population is sparse. We conducted a multicentre test-negative case–control study to estimate IVE against hospitalised laboratoryconfirmed influenza in the target population in 18 hospitals in France, Italy, Lithuania and the Navarre and Valencia regions in Spain. All hospitalised patients aged ≥18 years, belonging to the target population presenting with influenza-like illness symptom onset within seven days were swabbed. Patients positive by reverse transcription polymerase chain reaction for influenza virus were cases and those negative were controls. Using logistic regression, we calculated IVE for each influenza virus subtype and adjusted it for month of symptom onset, study site, age and chronic conditions. Of the 1,972 patients included, 116 were positive for influenza A(H1N1)pdm09, 58 for A(H3N2) and 232 for influenza B. Adjusted IVE was 21.3% (95% confidence interval (CI): -25.2 to 50.6; n=1,628), 61.8% (95% CI: 26.8 to 80.0; n=557) and 43.1% (95% CI: 21.2 to 58.9; n=1,526) against influenza A(H1N1) pdm09, A(H3N2) and B respectively. Our results suggest that the 2012/13 IVE was moderate against influenza A(H3N2) and B and low against influenza A(H1N1) pdm09.

AB - While influenza vaccines aim to decrease the incidence of severe influenza among high-risk groups, evidence of influenza vaccine effectiveness (IVE) among the influenza vaccine target population is sparse. We conducted a multicentre test-negative case–control study to estimate IVE against hospitalised laboratoryconfirmed influenza in the target population in 18 hospitals in France, Italy, Lithuania and the Navarre and Valencia regions in Spain. All hospitalised patients aged ≥18 years, belonging to the target population presenting with influenza-like illness symptom onset within seven days were swabbed. Patients positive by reverse transcription polymerase chain reaction for influenza virus were cases and those negative were controls. Using logistic regression, we calculated IVE for each influenza virus subtype and adjusted it for month of symptom onset, study site, age and chronic conditions. Of the 1,972 patients included, 116 were positive for influenza A(H1N1)pdm09, 58 for A(H3N2) and 232 for influenza B. Adjusted IVE was 21.3% (95% confidence interval (CI): -25.2 to 50.6; n=1,628), 61.8% (95% CI: 26.8 to 80.0; n=557) and 43.1% (95% CI: 21.2 to 58.9; n=1,526) against influenza A(H1N1) pdm09, A(H3N2) and B respectively. Our results suggest that the 2012/13 IVE was moderate against influenza A(H3N2) and B and low against influenza A(H1N1) pdm09.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Case-Control Studies

KW - Europe

KW - European Union

KW - Female

KW - Hospitalization

KW - Humans

KW - Influenza A Virus, H1N1 Subtype

KW - Influenza A Virus, H3N2 Subtype

KW - Influenza B virus

KW - Influenza Vaccines

KW - Influenza, Human

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Seasons

KW - Sentinel Surveillance

KW - Treatment Outcome

KW - Vaccination

KW - Young Adult

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Case-Control Studies

KW - Europe

KW - European Union

KW - Female

KW - Hospitalization

KW - Humans

KW - Influenza A Virus, H1N1 Subtype

KW - Influenza A Virus, H3N2 Subtype

KW - Influenza B virus

KW - Influenza Vaccines

KW - Influenza, Human

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Seasons

KW - Sentinel Surveillance

KW - Treatment Outcome

KW - Vaccination

KW - Young Adult

UR - http://hdl.handle.net/10807/171181

U2 - 10.2807/1560-7917.ES2015.20.2.21011

DO - 10.2807/1560-7917.ES2015.20.2.21011

M3 - Article

VL - 20

SP - 9

EP - 20

JO - Eurosurveillance

JF - Eurosurveillance

SN - 1560-7917

ER -