2-Substituted 3-Arylindoles Through Palladium-Catalyzed Arylative Cyclization of 2-Alkynyltrifluoroacetanilides with Arylboronic Acids under Oxidative Conditions

Antonio Arcadi; Sandro Cacchi; Giancarlo Fabrizi; Antonella Goggiamani; Antonia Iazzetti; Fabio Marinelli

doi:10.1039/c2ob27125g

2-Substituted 3-Arylindoles Through Palladium-Catalyzed Arylative Cyclization of 2-Alkynyltrifluoroacetanilides with Arylboronic Acids under Oxidative Conditions

Antonio Arcadi^*
, Sandro Cacchi
, Giancarlo Fabrizi
, Antonella Goggiamani
, Antonia Iazzetti
, Fabio Marinelli

^*Autore corrispondente per questo lavoro

University of L'Aquila
University of Rome La Sapienza

Risultato della ricerca: Contributo in rivista › Articolo

Abstract

Free NH 2-substituted 3-arylindoles have been prepared usually in\r\ngood to high yields through the palladium-catalyzed reaction of\r\nreadily available 2-alkynyltrifluoroacetanilides with arylboronic\r\nacids under oxidative conditions. The reaction tolerates a variety\r\nof useful functional groups both in the arylboronic acid and in the\r\nalkyne, including chloro, formyl, and ester groups.

Lingua originale	Inglese
pagine (da-a)	no-no
Rivista	CHEM INFORM
Volume	44
Numero di pubblicazione	22
DOI	https://doi.org/10.1039/c2ob27125g
Stato di pubblicazione	Pubblicato - 2013

All Science Journal Classification (ASJC) codes

Biochimica
Chimica Fisica e Teorica
Chimica Organica

Keywords

inglese

Accesso al documento

10.1039/c2ob27125g

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T1 - 2-Substituted 3-Arylindoles Through Palladium-Catalyzed Arylative Cyclization of 2-Alkynyltrifluoroacetanilides with Arylboronic Acids under Oxidative Conditions

AU - Arcadi, Antonio

AU - Cacchi, Sandro

AU - Fabrizi, Giancarlo

AU - Goggiamani, Antonella

AU - Iazzetti, Antonia

AU - Marinelli, Fabio

PY - 2013

Y1 - 2013

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AB - Free NH 2-substituted 3-arylindoles have been prepared usually in\r\ngood to high yields through the palladium-catalyzed reaction of\r\nreadily available 2-alkynyltrifluoroacetanilides with arylboronic\r\nacids under oxidative conditions. The reaction tolerates a variety\r\nof useful functional groups both in the arylboronic acid and in the\r\nalkyne, including chloro, formyl, and ester groups.

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2-Substituted 3-Arylindoles Through Palladium-Catalyzed Arylative Cyclization of 2-Alkynyltrifluoroacetanilides with Arylboronic Acids under Oxidative Conditions

Abstract

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