17beta-estradiol counteracts neuropathic pain: a behavioral, immunohistochemical, and proteomic investigation on sex-related differences in mice

Andrea Urbani, Valentina Vacca, Sara Marinelli, Luisa Pieroni, Siro Luvisetto, Flaminia Pavone

Risultato della ricerca: Contributo in rivistaArticolo in rivista

26 Citazioni (Scopus)

Abstract

Sex differences play a role in pain sensitivity, efficacy of analgesic drugs and prevalence of neuropathic pain, even if the underlying mechanisms are far from being understood. We demonstrate that male and female mice react differently to structural and functional changes induced by sciatic nerve ligature, used as model of neuropathic pain. Male mice show a gradual decrease of allodynia and a complete recovery while, in females, allodynia and gliosis are still present four months after neuropathy induction. Administration of 17 beta-estradiol is able to significantly attenuate this difference, reducing allodynia and inducing a complete recovery also in female mice. Parallel to pain attenuation, 17 beta-estradiol treated-mice show a functional improvement of the injured limb, a faster regenerative process of the peripheral nerve and a decreased neuropathy-induced gliosis. These results indicate beneficial effects of 17 beta-estradiol on neuropathic pain and neuronal regeneration and focuses on the importance of considering gonadal hormones also in clinical studies.
Lingua originaleEnglish
pagine (da-a)1-18
Numero di pagine18
RivistaScientific Reports
Volume6
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • ESTROGEN-RECEPTOR-ALPHA
  • SPINAL DORSAL-HORN

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