123I-MIBG Radioaerosol lung clearance in COPD patients with fixed and partially reversible obstruction to evacuate the functional status of pulmonary adrenergic innervation

Alessandro Giordano, Leonello Fuso, Maria Lucia Calcagni, Raffaele Antonelli Incalzi, Francesca Reale, Riccardo Pistelli, Salvatore Basso, Valeria Boniello

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

Abstract

In order to test the hypothesis that a greater sympathetic activity underlies partial reversibility of the bronchial obstruction in selected patients with chronic obstructive pulmonary disease (COPD), we assessed the pulmonary clearance of inhaled I-meta-iodobenzylguanidine ( I-MIBG) radioaerosol in 10 patients with fixed and nine with reversible obstruction. The clearance of inhaled I-MIBG is known to be inversely related to I-MIBG uptake by adrenergic terminals. Groups were matched for age and judged free from confounding comorbidity. The penetration index did not distinguish between the groups (fixed obstruction, 97.39+/-14.59%; reversible obstruction, 89.09+/-19.95%; P=0.659); this excludes the possibility that the inequality of tracer penetration could affect I-MIBG clearance. The I-MIBG clearance was 140.92+/-7.67 min in patients with fixed obstruction and 151.08+/-31.54 min in patients with reversible obstruction ( P=0.604). In conclusion, COPD patients with fixed and reversible obstruction show comparable binding of the tracer to adrenergic pulmonary receptors. Thus, a greater receptor responsiveness or post-receptor mechanism probably underlies the partial reversibility of bronchial obstruction.
Lingua originaleEnglish
pagine (da-a)1217-1220
Numero di pagine4
RivistaNuclear Medicine Communications
Stato di pubblicazionePubblicato - 2002

Keywords

  • mibg
  • radioaereosol

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