TY - CHAP
T1 - ω-3 PUFAs and colon cancer: experimental studies and human interventional trials
AU - Serini, Simona
AU - Piccioni, Elisabetta
AU - Calviello, Gabriella
PY - 2010
Y1 - 2010
N2 - Colon cancer represents one of the most frequent forms of cancer worldwide. There is plenty of evidence to support the notion that chemoprevention is a major component of colon cancer control, and that dietary fats influence the rate of incidence of this kind of cancer. In particular, a variety of experimental studies conducted on animals subject to chemical carcinogenesis of colon, transplanted with colon cancer cells, or representing a genetic model of colon cancer, have demonstrated the ability of diets at high content of ω-3 polyunsaturated fatty acids (PUFAs) to reduce the risk, growth and progression of colon cancer. Several of these studies have also emphasized the importance of a reduced dietary ω-6 PUFA/ω-3 PUFA ratio to diminish the risk. The beneficial anti-tumor effects of ω-3 PUFAs have been also largely demonstrated in colon cancer cells treated in vitro with these fatty acids. The synergic action of combinations of ω-3 PUFAs and other anti-neoplastic agents have been also demonstrated both in vivo and in vitro. On the contrary, just a few human interventional trials have been conducted so far, but there is complete agreement among them and with the experimental studies on the anti-tumor efficacy of increased dietary intakes of ω-3 PUFAs.
AB - Colon cancer represents one of the most frequent forms of cancer worldwide. There is plenty of evidence to support the notion that chemoprevention is a major component of colon cancer control, and that dietary fats influence the rate of incidence of this kind of cancer. In particular, a variety of experimental studies conducted on animals subject to chemical carcinogenesis of colon, transplanted with colon cancer cells, or representing a genetic model of colon cancer, have demonstrated the ability of diets at high content of ω-3 polyunsaturated fatty acids (PUFAs) to reduce the risk, growth and progression of colon cancer. Several of these studies have also emphasized the importance of a reduced dietary ω-6 PUFA/ω-3 PUFA ratio to diminish the risk. The beneficial anti-tumor effects of ω-3 PUFAs have been also largely demonstrated in colon cancer cells treated in vitro with these fatty acids. The synergic action of combinations of ω-3 PUFAs and other anti-neoplastic agents have been also demonstrated both in vivo and in vitro. On the contrary, just a few human interventional trials have been conducted so far, but there is complete agreement among them and with the experimental studies on the anti-tumor efficacy of increased dietary intakes of ω-3 PUFAs.
KW - clinical trials
KW - colon cancer
KW - experimental studies
KW - n-3 PUFA
KW - clinical trials
KW - colon cancer
KW - experimental studies
KW - n-3 PUFA
UR - http://hdl.handle.net/10807/23257
U2 - 10.1007/978-90-481-0_3
DO - 10.1007/978-90-481-0_3
M3 - Chapter
SN - 978-90-481-3578-3
T3 - Dietary Omega-3 Polyunsaturated Fatty Acids and Cancer
SP - 67
EP - 89
BT - Dietary omega-3 polyunsaturated fatty acids and cancer
A2 - CALVIELLO, GABRIELLA
A2 - SERINI, SIMONA
ER -