Supplementary Material for: Non-Pathogenic Aspergillus Oryzae Acute Exogenous Endophthalmitis after Penetrating Keratoplasty: The first case report in the literature.

The authors report a singular case of post-operative exogenous fungal endophthalmitis caused by a non-pathogenic fungal agent: the Aspergillus Oryzae. A 75-year-old Caucasian woman with post-penetrating keratoplasty fungal endophthalmitis due to a non-pathogenic Aspergillus Oryzae, resistant to the current azoles anti-fungal agents, was treated with subtotal vitrectomy, intravitreal injection and systemic Voriconazole therapy. Complete resolution of the endophthalmitis occurred after two subsequent intravitreal injections and 2 months long systemic delivery of Voriconazole. The quick identification of the fungal agent allowed immediate and targeted therapy. In the article, the safety and efficacy of both systemic and intravitreal Voriconazole treatment are discussed.