Raw data related to: "Cerebellar dentate nucleus functional connectivity with cerebralcortex in Alzheimer's disease and memory: a seed-based approach"

Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by specific patterns ofgray and white matter damage and cognitive/behavioral manifestations. The cerebellum has also beenimplicated in the pathophysiology of AD. Because the cerebellum is known to have strong functionalconnectivity (FC) with associative cerebral cortex regions, it is possible to hypothesize that it is incor-porated into intrinsic FC networks relevant to cognitive manifestation of AD. In the present study, thecerebellar dentate nucleus, the largest cerebellar nucleus and the major output channel to the cerebralcortex, was chosen as the region of interest to test potential cerebellocerebral FC alterations and cor-relations with patients' memory impairment in a group of patients with AD. Compared to controls,patients with AD showed an increase in FC between the dentate nucleus and regions of the lateraltemporal lobe. This study demonstrates that lower memory performances in AD may be related toaltered FC within specific cerebellocortical functional modules, thus suggesting the cerebellar contri-bution to AD pathophysiology and typical memory dysfunctions.