Influenza and associated co-infections in critically ill immunosuppressed patients

  • Ignacio Martin-Loeches (Creatore)
  • Virginie Lemiale (Creatore)
  • Pierce Geoghegan (Creatore)
  • Mary Aisling Mcmahon (Creatore)
  • Peter Pickkers (Creatore)
  • Marcio Soares (Creatore)
  • Anders Perner (Creatore)
  • Tine Sylvest Meyhoff (Creatore)
  • Ramin Brandt Bukan (Creatore)
  • Jordi Rello (Creatore)
  • Philippe R. Bauer (Creatore)
  • Andry van de Louw (Contributore)
  • Fabio Silvio Taccone (Creatore)
  • Jorge Salluh (Creatore)
  • Pleun Hemelaar (Creatore)
  • Peter Schellongowski (Creatore)
  • Katerina Rusinova (Creatore)
  • Nicolas Terzi (Creatore)
  • Sangeeta Mehta (Creatore)
  • Massimo Antonelli (Creatore)
  • Achille Kouatchet (Creatore)
  • Pål Klepstad (Creatore)
  • Miia Valkonen (Creatore)
  • Precious Pearl Landburg (Creatore)
  • Andreas Barratt-Due (Creatore)
  • Fabrice Bruneel (Creatore)
  • Frédéric Pène (Creatore)
  • Victoria Metaxa (Creatore)
  • Anne Sophie Moreau (Creatore)
  • Virginie Souppart (Creatore)
  • Gaston Burghi (Creatore)
  • Christophe Girault (Creatore)
  • Ulysses V. A. Silva (Creatore)
  • Luca Montini (Creatore)
  • François Barbier (Creatore)
  • Lene B. Nielsen (Creatore)
  • Benjamin Gaborit (Creatore)
  • Djamel Mokart (Creatore)
  • Sylvie Chevret (Creatore)
  • Elie Azoulay (Creatore)

Dataset

Description

Abstract Background It is unclear whether influenza infection and associated co-infection are associated with patient-important outcomes in critically ill immunocompromised patients with acute respiratory failure. Methods Preplanned secondary analysis of EFRAIM, a prospective cohort study of 68 hospitals in 16 countries. We included 1611 patients aged 18 years or older with non-AIDS-related immunocompromise, who were admitted to the ICU with acute hypoxemic respiratory failure. The main exposure of interest was influenza infection status. The primary outcome of interest was all-cause hospital mortality, and secondary outcomes ICU length of stay (LOS) and 90-day mortality. Results Influenza infection status was categorized into four groups: patients with influenza alone (n = 95, 5.8%), patients with influenza plus pulmonary co-infection (n = 58, 3.6%), patients with non-influenza pulmonary infection (n = 820, 50.9%), and patients without pulmonary infection (n = 638, 39.6%). Influenza infection status was associated with a requirement for intubation and with LOS in ICU (P 
Dati resi disponibili2019
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