Additional file 7: Figure S6. of MYH7-related myopathies: clinical, histopathological and imaging findings in a cohort of Italian patients

COILS prediction of the effect of mutations in the LMM region on the probability of the myosin tails forming a coiled coil. COILS analysis of residues 1193-1805, using a MTIDK matrix and scanning windows of 14 (green line), 21 (blu line) and 28 (red line) amino acids, shows that all the 4 novel distal-myopathy mutations (p.Ser1435Pro, p.Ala1439Pro, p.Ala1603Pro and Glu1619Lys) impact the ability of the myosin tail to form a coiled coil (or hamper a coiled-coil conformation). Arrow indicates the position of the mutated amino acids. (JPG 183Â kb)