Additional file 5: of G-quadruplex ligand RHPS4 radiosensitizes glioblastoma xenograft in vivo through a differential targeting of bulky differentiated- and stem-cancer cells

  • F. Berardinelli (Contributor)
  • M Tanori (Contributor)
  • D. Muoio (Contributor)
  • M Buccarelli (Contributor)
  • Masi A. Di (Contributor)
  • S. Leone (Contributor)
  • L. Ricci-Vitiani (Contributor)
  • R. Pallini (Fondazione Policlinico Universitario Agostino Gemelli IRCCS) (Contributor)
  • M. Mancuso (Contributor)
  • A Antoccia (Contributor)

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Description

Figure S5. RHPS4 does not affect stem cell markers in U251MG-Sph and GSCs. Western blot analysis of stemness markers SOX2, NESTIN and CD44 in response to RHPS4 treatment in GSCs#1, #61, #83 and #163 (A) and U251MG-Adh and U251MG-Sph cells (B). Protein levels of CD44 (C), SOX2 (D) and NESTIN (E). Box plot represents mean, maximum and minimum values (n = 2). Gene expression profile for CD44 (F), SOX2 (G) and NESTIN (H). Box plot represents mean, maximum and minimum values (n = 2). (TIF 21948 kb)
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