Additional file 2: of Preferential MGMT methylation could predispose a subset of KIT/PDGFRA-WT GISTs, including SDH-deficient ones, to respond to alkylating agents

Figure S2. Chromatogram showing the SDHx mutations found in GISTs (T) and in normal tissue (N) in cases 42–48. Case 42: heterozygous SDHA exon 5 mutation in normal tissue and homozygous in GIST. Case 43: somatic heterozygous SDHA exons 1 and 13 mutations in GIST. Case 44: somatic heterozygous SDHA exon 9 mutation in GIST. Case 45: somatic homozygous SDHA exon 10 mutation in GIST. Case 46: somatic homozygous SDHB exon 6 mutation in GIST. Case 47: somatic heterozygous SDHC exon 4 mutation in GIST. Case 48: heterozygous SDHA exon 9 mutation in GIST (germline not tested). (SDHx mutations found in cases 40 and 41 have been previously reported—see ref. [26] of the main text). (PPTX 1802 kb)