A novel oral micellar fenretinide formulation with enhanced bioavailability and antitumour activity against multiple tumours from cancer stem cells

  • Isabella Orienti (Creator)
  • Valentina Salvati (Creator)
  • Giovanni Sette (Creator)
  • Massimo Zucchetti (Creator)
  • Lucilla Bongiorno-Borbone (Creator)
  • Angelo Peschiaroli (Creator)
  • Lello Zolla (Creator)
  • Federica Francescangeli (Creator)
  • Mariella Ferrari (Creator)
  • Cristina Matteo (Creator)
  • Ezia Bello (Creator)
  • Antonio Di Virgilio (Contributor)
  • Mario Falchi (Creator)
  • Maria Laura De Angelis (Contributor)
  • Marta Baiocchi (Creator)
  • Gerry Melino (Creator)
  • Ruggero De Maria Marchiano (Contributor)
  • Ann Zeuner (Creator)
  • Adriana Eramo (Creator)

Dataset

Description

Abstract Background An increasing number of anticancer agents has been proposed in recent years with the attempt to overcome treatment-resistant cancer cells and particularly cancer stem cells (CSC), the major culprits for tumour resistance and recurrence. However, a huge obstacle to treatment success is the ineffective delivery of drugs within the tumour environment due to limited solubility, short circulation time or inconsistent stability of compounds that, together with concomitant dose-limiting systemic toxicity, contribute to hamper the achievement of therapeutic drug concentrations. The synthetic retinoid Fenretinide (4-hydroxy (phenyl)retinamide; 4-HPR) formerly emerged as a promising anticancer agent based on pre-clinical and clinical studies. However, a major limitation of fenretinide is traditionally represented by its poor aqueous solubility/bioavailability due to its hydrophobic nature, that undermined the clinical success of previous clinical trials. Methods Here, we developed a novel nano-micellar fenretinide formulation called bionanofenretinide (Bio-nFeR), based on drug encapsulation in an ion-pair stabilized lipid matrix, with the aim to raise fenretinide bioavailability and antitumour efficacy. Results Bio-nFeR displayed marked antitumour activity against lung, colon and melanoma CSC both in vitro and in tumour xenografts, in absence of mice toxicity. Bio-nFeR is suitable for oral administration, reaching therapeutic concentrations within tumours and an unprecedented therapeutic activity in vivo as single agent. Conclusion Altogether, our results indicate Bio-nFeR as a novel anticancer agent with low toxicity and high activity against tumourigenic cells, potentially useful for the treatment of solid tumours of multiple origin.
Dati resi disponibili2019
Editorefigshare

Cita questo