Zika virus infection induces MiR34c expression in glioblastoma stem cells: new perspectives for brain tumor treatments

Gioacchin Iannolo; Maria Rita Sciuto; Nicola Cuscino; Roberto Pallini; Bruno Douradinha; Lucia Ricci Vitiani; Ruggero De Maria Marchiano; Pier Giulio Conaldi

doi:10.1038/s41419-019-1499-z

Zika virus infection induces MiR34c expression in glioblastoma stem cells: new perspectives for brain tumor treatments

Gioacchin Iannolo, Maria Rita Sciuto, Nicola Cuscino, Roberto Pallini, Bruno Douradinha, Lucia Ricci Vitiani, Ruggero De Maria Marchiano, Pier Giulio Conaldi

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7 Citations (Scopus)

Abstract

Zika virus (ZIKV) is a flavivirus with a marked effect on fetal nervous system development. ZIKV treatment has recently been found to also have a benefit against glioblastoma, a highly aggressive brain tumor with a poor prognosis. The reported data do not completely explain the mechanism beyond this effect. Nevertheless, in the majority of the cases no adverse effect has been found in healthy adult humans. In this study, we characterized the ZIKV infection mechanism on glioblastoma stem cells, which are considered responsible for the tumor progression and resistance to conventional therapies. Moreover, we explain why the action of this virus is directed to the stem cells in the nervous system counterpart. Our results confirm the effectiveness of ZIKV treatment against glioblastoma, indicating novel molecular targets that can be introduced for more powerful therapies.

Original language	English
Pages (from-to)	N/A-N/A
Journal	CELL DEATH & DISEASE
Volume	10
DOIs	https://doi.org/10.1038/s41419-019-1499-z
Publication status	Published - 2019

Keywords

zika

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Zika virus infection induces MiR34c expression in glioblastoma stem cells: new perspectives for brain tumor treatments",

abstract = "Zika virus (ZIKV) is a flavivirus with a marked effect on fetal nervous system development. ZIKV treatment has recently been found to also have a benefit against glioblastoma, a highly aggressive brain tumor with a poor prognosis. The reported data do not completely explain the mechanism beyond this effect. Nevertheless, in the majority of the cases no adverse effect has been found in healthy adult humans. In this study, we characterized the ZIKV infection mechanism on glioblastoma stem cells, which are considered responsible for the tumor progression and resistance to conventional therapies. Moreover, we explain why the action of this virus is directed to the stem cells in the nervous system counterpart. Our results confirm the effectiveness of ZIKV treatment against glioblastoma, indicating novel molecular targets that can be introduced for more powerful therapies.",

keywords = "zika, zika",

author = "Gioacchin Iannolo and Sciuto, {Maria Rita} and Nicola Cuscino and Roberto Pallini and Bruno Douradinha and {Ricci Vitiani}, Lucia and {De Maria Marchiano}, Ruggero and Conaldi, {Pier Giulio}",

year = "2019",

doi = "10.1038/s41419-019-1499-z",

language = "English",

volume = "10",

pages = "N/A--N/A",

journal = "CELL DEATH & DISEASE",

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TY - JOUR

T1 - Zika virus infection induces MiR34c expression in glioblastoma stem cells: new perspectives for brain tumor treatments

AU - Iannolo, Gioacchin

AU - Sciuto, Maria Rita

AU - Cuscino, Nicola

AU - Pallini, Roberto

AU - Douradinha, Bruno

AU - Ricci Vitiani, Lucia

AU - De Maria Marchiano, Ruggero

AU - Conaldi, Pier Giulio

PY - 2019

Y1 - 2019

N2 - Zika virus (ZIKV) is a flavivirus with a marked effect on fetal nervous system development. ZIKV treatment has recently been found to also have a benefit against glioblastoma, a highly aggressive brain tumor with a poor prognosis. The reported data do not completely explain the mechanism beyond this effect. Nevertheless, in the majority of the cases no adverse effect has been found in healthy adult humans. In this study, we characterized the ZIKV infection mechanism on glioblastoma stem cells, which are considered responsible for the tumor progression and resistance to conventional therapies. Moreover, we explain why the action of this virus is directed to the stem cells in the nervous system counterpart. Our results confirm the effectiveness of ZIKV treatment against glioblastoma, indicating novel molecular targets that can be introduced for more powerful therapies.

AB - Zika virus (ZIKV) is a flavivirus with a marked effect on fetal nervous system development. ZIKV treatment has recently been found to also have a benefit against glioblastoma, a highly aggressive brain tumor with a poor prognosis. The reported data do not completely explain the mechanism beyond this effect. Nevertheless, in the majority of the cases no adverse effect has been found in healthy adult humans. In this study, we characterized the ZIKV infection mechanism on glioblastoma stem cells, which are considered responsible for the tumor progression and resistance to conventional therapies. Moreover, we explain why the action of this virus is directed to the stem cells in the nervous system counterpart. Our results confirm the effectiveness of ZIKV treatment against glioblastoma, indicating novel molecular targets that can be introduced for more powerful therapies.

KW - zika

UR - http://hdl.handle.net/10807/167055

U2 - 10.1038/s41419-019-1499-z

DO - 10.1038/s41419-019-1499-z

M3 - Article

SN - 2041-4889

VL - 10

SP - N/A-N/A

JO - CELL DEATH & DISEASE

JF - CELL DEATH & DISEASE

ER -

Zika virus infection induces MiR34c expression in glioblastoma stem cells: new perspectives for brain tumor treatments

Abstract

Keywords

UN SDGs

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