X chromosome gain in male breast cancer

Riccardo Masetti, Enrico Di Oto, Valentina Monti, Maria C. Cucchi, Zsuzsanna Varga, Maria P. Foschini

Research output: Contribution to journalArticle

10 Citations (Scopus)


Male breast cancer (MBC) is an uncommon disease whose molecular profile is not well known. X chromosome gain has been described as a marker of aggressive behavior in female breast cancer. The aim of this study is to investigate the role of the X chromosome in male breast cancer. Twenty cases of male breast invasive ductal carcinoma were retrieved and compared with 10 cases of gynecomastia. Cases were tested by fluorescence in situ hybridization to assess a cytogenetic profile for the X chromosome. The X chromosome status was compared with histopathologic features and stage at presentation. All MBC cases harbored an X chromosome gain (100%) in a variable percentage of neoplastic cells, ranging from 31% to 85% (mean, 59%). On the contrary, all cases of gynecomastia showed wild X chromosome asset. The patients' age at surgery and tumor grading showed a statistically significant correlation (P = .0188-.04), with the percentages of neoplastic cells showing an X chromosome gain. These data suggest that this X chromosome gain plays a role in the neoplastic transformation of male breast epithelial cells.
Original languageEnglish
Pages (from-to)1908-1912
Number of pages5
JournalHuman Pathology
Publication statusPublished - 2015


  • FISH
  • Genetic marker
  • Invasive ductal carcinoma
  • Male breast cancer
  • X chromosome

Fingerprint Dive into the research topics of 'X chromosome gain in male breast cancer'. Together they form a unique fingerprint.

Cite this