Viscous forces are predominant in the zona pellucida mechanical resistance

Massimiliano Papi, Giuseppe Maulucci, Marco De Spirito, Alessandro Maiorana, Cécile Douet, Tiziana Parasassi, Roberto Brunelli, Ghylène Goudet

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

The zona pellucida (ZP) is a multilayer glycoprotein spherical shell surrounding mammalian eggs. The ZP's mechanical response plays a crucial role in mammalian fertilization and is a parameter commonly adopted in "in vitro fertilization" to characterize the oocytes quality. While it is assumed that ZP mechanical response is purely elastic, here we prove that dissipative forces cannot be neglected. Physiologically, this evidence implies that an increase in the spermatozoa motility can induce dramatic changes on the ZP reaction force turning ZP shell in an impenetrable barrier leading to fertility impairments.
Original languageEnglish
Pages (from-to)043703-1-043703-4
Number of pages4
JournalApplied Physics Letters
Volume102
DOIs
Publication statusPublished - 2013

Keywords

  • Viscosity
  • Zona Pellucida

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