Value of serum nonceruloplasmin copper for prediction of mild cognitive impairment conversion to Alzheimer disease

Rosanna Squitti; Roberta Ghidoni; Mariacristina Siotto; Mariacarla Ventriglia; Luisa Benussi; Anna Paterlini; Mariachiara Magri; Giuliano Binetti; Emanuele Cassetta; Deborah Caprara; Fabrizio Vernieri; Paolo Maria Rossini; Patrizio Pasqualetti

doi:10.1002/ana.24136

Value of serum nonceruloplasmin copper for prediction of mild cognitive impairment conversion to Alzheimer disease

Rosanna Squitti, Roberta Ghidoni, Mariacristina Siotto, Mariacarla Ventriglia, Luisa Benussi, Anna Paterlini, Mariachiara Magri, Giuliano Binetti, Emanuele Cassetta, Deborah Caprara, Fabrizio Vernieri, Paolo Maria Rossini, Patrizio Pasqualetti

Università Cattolica del Sacro Cuore

Research output: Contribution to journal › Article

71 Citations (Scopus)

Abstract

Meta-analyses show that nonbound ceruloplasmin (non-Cp) copper (also known as free or labile copper) in serum is higher in patients with Alzheimer disease (AD). It differentiates subjects with mild cognitive impairment (MCI) from healthy controls. However, a longitudinal study on an MCI cohort has not yet been performed to assess the accuracy of non-Cp copper for the prediction of conversion from MCI to AD during a long-term follow-up.

Original language	English
Pages (from-to)	574-580
Number of pages	7
Journal	Annals of Neurology
Volume	75
DOIs	https://doi.org/10.1002/ana.24136
Publication status	Published - 2014

Keywords

Alzheimer Disease
Apolipoprotein E4
Ceruloplasmin
Cognition Disorders
Copper
Disease Progression
Female
Humans
Longitudinal Studies
Male
Neuropsychological Tests
Predictive Value of Tests
Probability
Risk Factors

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Squitti, R., Ghidoni, R., Siotto, M., Ventriglia, M., Benussi, L., Paterlini, A., Magri, M., Binetti, G., Cassetta, E., Caprara, D., Vernieri, F., Rossini, P. M., & Pasqualetti, P. (2014). Value of serum nonceruloplasmin copper for prediction of mild cognitive impairment conversion to Alzheimer disease. Annals of Neurology, 75, 574-580. https://doi.org/10.1002/ana.24136

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abstract = "Meta-analyses show that nonbound ceruloplasmin (non-Cp) copper (also known as free or labile copper) in serum is higher in patients with Alzheimer disease (AD). It differentiates subjects with mild cognitive impairment (MCI) from healthy controls. However, a longitudinal study on an MCI cohort has not yet been performed to assess the accuracy of non-Cp copper for the prediction of conversion from MCI to AD during a long-term follow-up.",

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author = "Rosanna Squitti and Roberta Ghidoni and Mariacristina Siotto and Mariacarla Ventriglia and Luisa Benussi and Anna Paterlini and Mariachiara Magri and Giuliano Binetti and Emanuele Cassetta and Deborah Caprara and Fabrizio Vernieri and Rossini, {Paolo Maria} and Patrizio Pasqualetti",

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doi = "10.1002/ana.24136",

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T1 - Value of serum nonceruloplasmin copper for prediction of mild cognitive impairment conversion to Alzheimer disease

AU - Squitti, Rosanna

AU - Ghidoni, Roberta

AU - Siotto, Mariacristina

AU - Ventriglia, Mariacarla

AU - Benussi, Luisa

AU - Paterlini, Anna

AU - Magri, Mariachiara

AU - Binetti, Giuliano

AU - Cassetta, Emanuele

AU - Caprara, Deborah

AU - Vernieri, Fabrizio

AU - Rossini, Paolo Maria

AU - Pasqualetti, Patrizio

PY - 2014

Y1 - 2014

N2 - Meta-analyses show that nonbound ceruloplasmin (non-Cp) copper (also known as free or labile copper) in serum is higher in patients with Alzheimer disease (AD). It differentiates subjects with mild cognitive impairment (MCI) from healthy controls. However, a longitudinal study on an MCI cohort has not yet been performed to assess the accuracy of non-Cp copper for the prediction of conversion from MCI to AD during a long-term follow-up.

AB - Meta-analyses show that nonbound ceruloplasmin (non-Cp) copper (also known as free or labile copper) in serum is higher in patients with Alzheimer disease (AD). It differentiates subjects with mild cognitive impairment (MCI) from healthy controls. However, a longitudinal study on an MCI cohort has not yet been performed to assess the accuracy of non-Cp copper for the prediction of conversion from MCI to AD during a long-term follow-up.

KW - Alzheimer Disease

KW - Apolipoprotein E4

KW - Ceruloplasmin

KW - Cognition Disorders

KW - Copper

KW - Disease Progression

KW - Female

KW - Humans

KW - Longitudinal Studies

KW - Male

KW - Neuropsychological Tests

KW - Predictive Value of Tests

KW - Probability

KW - Risk Factors

KW - Alzheimer Disease

KW - Apolipoprotein E4

KW - Ceruloplasmin

KW - Cognition Disorders

KW - Copper

KW - Disease Progression

KW - Female

KW - Humans

KW - Longitudinal Studies

KW - Male

KW - Neuropsychological Tests

KW - Predictive Value of Tests

KW - Probability

KW - Risk Factors

UR - http://hdl.handle.net/10807/72452

U2 - 10.1002/ana.24136

DO - 10.1002/ana.24136

M3 - Article

SN - 1531-8249

VL - 75

SP - 574

EP - 580

JO - Annals of Neurology

JF - Annals of Neurology

ER -

Value of serum nonceruloplasmin copper for prediction of mild cognitive impairment conversion to Alzheimer disease

Abstract

Keywords

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