Urinary kallikrein and kininase activity in normal and complicated by hypertension pregnancy

E Moneta, Sergio Ferrazzani, P Leardi, R Di Giglio, G Porcelli, Anna Rita Volpe

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Kallikrein and kininase activities were determined in urine of 58 hospitalized pregnant patients: 15 with E.P.H. gestosis, 10 with chronic hypertension, 18 with non proteinuric pregnancy induced hypertension, 15 with no hemodynamic disease as controls. All our cases with hypertension were treated with alpha-methyl-dopa. A significant increase in urinary kininase activity was shown by only E.P.H. gestosis group vs. controls. In the same group we found a significant decrease in urinary kallikrein activity vs. controls, in contrast with the results obtained previously, perhaps because of the different measuring method. The kininase/kallikrein ratio, theoretically indicative of kinins activity, increased significantly only in the E.P.H. gestosis group.
Original languageEnglish
Pages (from-to)305-311
Number of pages7
JournalAdvances in Experimental Medicine and Biology
Publication statusPublished - 1986

Keywords

  • pregnancy hypertension
  • urinary kallikrein

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