Upper limb function in Duchenne muscular dystrophy: 24 month longitudinal data.

Marika Pane, Eugenio Maria Mercuri, Giorgia Coratti, Claudia Brogna, Elena Stacy Mazzone, Michela Catteruccia, Fabio Cavallaro, Maria Francesca Ricci, Roberta Battini, Emilio Albamonte, Giovanni Baranello, Enrico Silvio Bertini, Anna Mayhew, Sonia Messina, Adele D Amico, Marianna Scutifero, Silvia Frosini, Valentina Lanzillotta, Giulia Colia, Filippo CavallaroEnrica Rolle, Roberta Petillo, Andrea Barp, Alice Gardani, Antonella Pini, Giulia Monaco, Maria Grazia D Angelo, Riccardo Zanin, Gian Luca Vita, Claudio Bruno, Tiziana Mongini, Federica Ricci, Elena Pegoraro, Luca Bello, Angela Berardinelli, Valeria Sansone, Luisa Politano, Maria Pia Sormani

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The aim of the study was to establish 24 month changes in upper limb function using a revised version of the performance of upper limb test (PUL 2.0) in a large cohort of ambulant and non-ambulant boys with Duchenne muscular dystrophy and to identify possible trajectories of progression. Of the 187 patients studied, 87 were ambulant (age range: 7-15.8 years), and 90 non-ambulant (age range: 9.08-24.78). The total scores changed significantly over time (p<0.001). Non-ambulant patients had lower total scores at baseline (mean 19.7) when compared to the ambulant ones (mean 38.4). They also had also a bigger decrease in total scores over 24 months compared to the ambulant boys (4.36 vs 2.07 points). Multivariate model analysis showed that the Performance of Upper Limb changes reflected the entry level and ambulation status, that were independently associated to the slope of Performance of Upper Limb changes. This information will be of help both in clinical practice and at the time of designing clinical trials.
Original languageEnglish
Pages (from-to)199223-199224
Number of pages2
JournalPLoS One
DOIs
Publication statusPublished - 2018

Keywords

  • Duchenne

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