7 Citations (Scopus)


Among somatic stem cells, those residing in the intestine represent a fascinating and poorly explored research field. Particularly, somatic stem cells reside in the small intestine at the level of the crypt base, in a constant balance between self-renewal and differentiation. Aim of the present review is to delve into the mechanisms that regulate the delicate equilibrium through which intestinal stem cells orchestrate intestinal architecture. To this aim, special focus will be addressed to identify the integrating signals from the surrounding niche, supporting a model whereby distinct cell populations facilitate homeostatic vs injury-induced regeneration.
Original languageEnglish
Pages (from-to)4671-4678
Number of pages8
JournalWorld Journal of Gastroenterology
Publication statusPublished - 2013


  • Animals
  • Biological Markers
  • Cell Differentiation
  • Cell Lineage
  • Cell Proliferation
  • Humans
  • Intestinal Diseases
  • Intestinal regeneration
  • Intestinal stem cells
  • Intestines
  • Lgr5
  • Niche
  • Organoids
  • Regeneration
  • Signal Transduction
  • Stem Cell Niche
  • Stem Cells


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