Update on matrix-assisted laser desorption ionization-time of flight mass spectrometry identification of filamentous fungi

Brunella Posteraro, Maurizio Sanguinetti, Laura S. Wilkendorf, Edmée Bowles, Jochem B. Buil, Henrich A.L. Van Der Lee, Paul E. Verweij

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS)-based species identification has found its place in many clinical routine diagnostic laboratories over the past years, allowing significantly reduced turnaround times and high-precision results. With regard to MALDI-TOF MS for filamentous fungi, here, we discuss different approaches for sample processing and growth conditions before analysis. In particular, we review the performances of different commercially available databases as well as the potential of complementary (self-constructed) in-house databases.
Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalJournal of Clinical Microbiology
Volume58
DOIs
Publication statusPublished - 2020

Keywords

  • Biotyper
  • Bruker
  • Filamentous fungi
  • Identification
  • In-house database
  • MALDI-TOF MS
  • Vitek

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