Understanding Growth Failure in Costello Syndrome: Increased Resting Energy Expenditure

Chiara Leoni; Roberta Onesimo; Valentina Giorgio; Antonella Diamanti; Daniela Giorgio; Lucilla Martini; Aurora Natalia Rossodivita; Marco Tartaglia; Giuseppe Zampino

doi:10.1016/j.jpeds.2015.11.076

Understanding Growth Failure in Costello Syndrome: Increased Resting Energy Expenditure

Chiara Leoni
, Roberta Onesimo
, Valentina Giorgio
, Antonella Diamanti
, Daniela Giorgio
, Lucilla Martini
, Aurora Natalia Rossodivita
, Marco Tartaglia
, Giuseppe Zampino

IRCCS Ospedale pediatrico Bambino Gesù - Roma

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Costello syndrome is a rare multisystem disorder caused by mutations in the proto-oncogene HRAS. Failure to thrive is one of its cardinal clinical features. This study documents that individuals with Costello syndrome have increased resting energy expenditure. We speculate this could be one of the potential mechanisms causing failure to thrive.

Original language	English
Pages (from-to)	322-324
Number of pages	3
Journal	THE JOURNAL OF PEDIATRICS
Volume	170
DOIs	https://doi.org/10.1016/j.jpeds.2015.11.076
Publication status	Published - 2016

Keywords

Pediatrics, Perinatology and Child Health

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10.1016/j.jpeds.2015.11.076

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abstract = "Costello syndrome is a rare multisystem disorder caused by mutations in the proto-oncogene HRAS. Failure to thrive is one of its cardinal clinical features. This study documents that individuals with Costello syndrome have increased resting energy expenditure. We speculate this could be one of the potential mechanisms causing failure to thrive.",

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author = "Chiara Leoni and Roberta Onesimo and Valentina Giorgio and Antonella Diamanti and Daniela Giorgio and Lucilla Martini and Rossodivita, \{Aurora Natalia\} and Marco Tartaglia and Giuseppe Zampino",

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AU - Leoni, Chiara

AU - Onesimo, Roberta

AU - Giorgio, Valentina

AU - Diamanti, Antonella

AU - Giorgio, Daniela

AU - Martini, Lucilla

AU - Rossodivita, Aurora Natalia

AU - Tartaglia, Marco

AU - Zampino, Giuseppe

PY - 2016

Y1 - 2016

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AB - Costello syndrome is a rare multisystem disorder caused by mutations in the proto-oncogene HRAS. Failure to thrive is one of its cardinal clinical features. This study documents that individuals with Costello syndrome have increased resting energy expenditure. We speculate this could be one of the potential mechanisms causing failure to thrive.

KW - Pediatrics, Perinatology and Child Health

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UR - http://www.elsevier.com/inca/publications/store/6/2/3/3/1/1/index.htt

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DO - 10.1016/j.jpeds.2015.11.076

M3 - Article

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JO - THE JOURNAL OF PEDIATRICS

JF - THE JOURNAL OF PEDIATRICS

ER -

Understanding Growth Failure in Costello Syndrome: Increased Resting Energy Expenditure

Abstract

Keywords

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