Uncommon BRAF mutations in the follicular variant of thyroid papillary carcinoma: New insights

Esther Rossi, Maurizio Martini, Celestino Pio Lombardi, Alfredo Pontecorvi, Luigi Maria Larocca, Tommaso Bizzarro, Sara Capodimonti, Tonia Cenci, Guido Fadda

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Mutational analysis is reshaping the practice of fine-needle aspiration cytology for the diagnosis of thyroid nodules. The v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) valine (V) to glutamic acid (E) substitution at codon 600 (BRAF(V600E)) is the most effective diagnostic/prognostic marker and is used mainly for papillary thyroid carcinomas (PTCs). Although BRAF(V600E) represents 95% of all BRAF mutations, uncommon BRAF mutations have been identified in thyroid carcinomas. For the current study, the authors evaluated morphologic (plump pink cells and sickle-shaped nuclei) anti-BRAF(V600E) antibody (VE1) immunocytochemical and molecular findings of BRAF mutations in PTCs and in the follicular variant of PTC (FVPC).
Original languageEnglish
Pages (from-to)593-602
Number of pages10
JournalCancer cytopathology
Volume123
DOIs
Publication statusPublished - 2015

Keywords

  • BRAF mutations
  • follicular neoplasms
  • follicular variant of papillary thyroid carcinoma
  • liquid-based cytology
  • papillary thyroid carcinoma

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