Umbilical cord blood as a source for red-blood-cell transfusion in neonatology: a systematic review

Maria Bianchi, Patrizia Papacci, Caterina Giovanna Valentini, Ombretta Barbagallo, Giovanni Vento, Luciana Teofili

Research output: Contribution to journalArticle

11 Citations (Scopus)


The prevention and treatment of anaemia in newborn patients made tremendous progress in the last decades. However, red-blood-cell (RBC) transfusions remain unavoidable in many neonates candidate to surgery and especially in preterm infants. In particular, anaemia occurring in neonates born at extremely low gestational age is actually severe and frequently requires transfusions. Several approaches have been explored to prevent or even to reduce the threshold and the frequency of RBC transfusions. Among these, umbilical cord blood (UCB) collection and processing to obtain RBC components for autologous or allogeneic transfusion have been extensively investigated. In this systematic review, we revised the literature concerning the use of UCB for either autologous or allogeneic transfusion purposes and we illustrated the rationale for a transfusion therapy tailored to extremely preterm neonates, based on RBC concentrates from allogeneic UCB donations.
Original languageEnglish
Pages (from-to)713-725
Number of pages13
JournalVox Sanguinis
Publication statusPublished - 2018


  • Anemia
  • Erythrocyte Transfusion
  • Fetal Blood
  • Hematology
  • Humans
  • Infant, Newborn
  • Neonatology
  • cord blood
  • individualized therapy
  • premature birth
  • transfusion


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