Treatment of the first tonic-clonic seizure does not affect long-term remission of epilepsy.

Salvatore Mazza, Maurizio A. Leone, Alessandra Solari, Ettore Beghi

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)

Abstract

We followed 419 patients with a first, unprovoked, primarily or secondarily generalized tonic-clonic seizure, randomized to immediate antiepileptic treatment or to treatment only in the event of seizure recurrence. The probability of achieving a 2-year remission was 72 vs 57% at 3 months, 84 to 79% at 3 years, and 85 to 86% at 10 years (p NS). The probability of entering 5-year remission was 47 to 40, 58 to 58, and 64 to 64% (p NS). Early treatment does not affect the long-term prognosis of epilepsy.
Original languageEnglish
Pages (from-to)2227-2229
Number of pages3
JournalNeurology
Publication statusPublished - 2006

Keywords

  • epilepsy
  • treatment

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