[Treatment of pancreatic necrosis and secondary pancreatic infections]

Translated title of the contribution: [Autom. eng. transl.] [Treatment of pancreatic necrosis and secondary pancreatic infections]

Giuseppe Brisinda, Gabriele Sganga, Daniele Matera, Giorgio Maria, Francesco Brandara, C Nigro, Im Civello

Research output: Contribution to journalArticle

Abstract

Acute pancreatitis is a disease capable of the widest clinical expression, ranging from mild discomfort to multiorgan failure and death. Moreover, the process may remain localized in the pancreas, or spread to regional tissues, or even involve remote organs. Despite several efforts, the pathophysiology of acute pancreatitis and its complications remains obscure. In the absence of an understanding of the pathogenesis and the reasons for the variations in severity, the study and management of acute pancreatitis has necessarily been empirical. There is little doubt that the development of pancreatic necrosis in patients with acute pancreatitis results in an increase in clinical severity and an escalation of the mortality risk when compared to interstitial pancreatitis. Furthermore, the mortality risk of patients with sterile pancreatic necrosis is markedly different from that of patients developing secondary infections in pre-existing pancreatic necrosis. Infected pancreatic necrosis is uniformly fatal, if untreated. While most authorities agree that surgical debridement is required for survival in patients with secondary pancreatic infections, the precise form of the subsequent drainage has become a matter of some controversy. In this paper we discuss the most recent insights relating to the nosographical classification of pancreatic necrosis and secondary pancreatic infections, along with an analysis of the findings in the literature regarding the surgical treatment of these conditions.
Translated title of the contribution[Autom. eng. transl.] [Treatment of pancreatic necrosis and secondary pancreatic infections]
Original languageItalian
Pages (from-to)455-468
Number of pages14
JournalChirurgia Italiana
Volume54
Publication statusPublished - 2002

Keywords

  • Abscess
  • Acute Disease
  • Anti-Bacterial Agents
  • Bacteria
  • Bacterial Infections
  • Humans
  • Necrosis
  • Pancreas
  • Pancreatic Diseases
  • Pancreatitis
  • Pancreatitis, Acute Necrotizing
  • Therapeutic Irrigation
  • Tomography, X-Ray Computed

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