Treadmill training in patients affected by Charcot-Marie-Tooth neuropathy: results of a multicenter, prospective, randomized, single-blind, controlled study

Luca Padua, Costanza Pazzaglia, L. Mori, A. Signori, V. Prada, D. Pareyson, G. Piscosquito, G. M. Fabrizi, A. Picelli, A. Schenone, Marina Grandis, Giovanni Maggi, Riccardo Zuccariono, Lucio Marinelli, Carlo Trompetto, Deborah Scorsone, Angelo Montesano, Davide Cattaneo, Eleonora Casati, Nicola SmaniaAnnalisa Brugnera, Carla Fontana, Daniele Munari

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background and purpose: Muscle-strengthening, stretching or proprioceptive treatments may slow symptom progression in Charcot-Marie-Tooth (CMT) neuropathy. The aim of the study was to evaluate safety and efficacy of treadmill training in CMT1A. Methods: We planned a multicenter, prospective, randomized, single-blind, controlled study. We recruited 53 outpatients affected by CMT1A and randomized them into two treatment groups: one underwent stretching and proprioceptive exercise, whereas the other was additionally treated with treadmill training (TreSPE). Primary outcome measures (OMs) were the walking evaluations and secondary OM was the balance assessment. All participants were assessed at baseline and after 3 and 6 months of treatment. Results: Most patients showed an improvement in at least one OM after 3 months [42/47 (89.4%)] and 6 months [38/40 (95%)] of treatment. No adverse events were reported in either group. Conclusions: The most important finding was that both stretching and proprioceptive exercise and treadmill training had an objective benefit on patients affected by CMT disease, without causing overwork weakness. We had a low rate of drop out and did not find deterioration in motor performance. Our results also confirm that applying evidence-based medicine methods to rehabilitative research is the correct way to test the efficacy of a treatment.
Original languageEnglish
Pages (from-to)280-287
Number of pages8
JournalEUROPEAN JOURNAL OF NEUROLOGY
Volume2020
DOIs
Publication statusPublished - 2020

Keywords

  • Charcot-Marie-Tooth

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