Transfusion strategies in non-bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine

Massimo Antonelli, Alexander P. Vlaar, Simon Oczkowski, Sanne De Bruin, Marije Wijnberge, Cecile Aubron, Philippe Aries, Jacques Duranteau, Nicole P. Juffermans, Jens Meier, Gavin J. Murphy, Riccardo Abbasciano, Marcella Muller, Akshay Shah, Anders Perner, Sofie Rygaard, Timothy S. Walsh, Gordon Guyatt, J. C. Dionne, Maurizio Cecconi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: To develop evidence-based clinical practice recommendations regarding transfusion practices in non-bleeding, critically ill adults. Design: A task force involving 13 international experts and three methodologists used the GRADE approach for guideline development. Methods: The task force identified four main topics: red blood cell transfusion thresholds, red blood cell transfusion avoidance strategies, platelet transfusion, and plasma transfusion. The panel developed structured guideline questions using population, intervention, comparison, and outcomes (PICO) format. Results: The task force generated 16 clinical practice recommendations (3 strong recommendations, 13 conditional recommendations), and identified five PICOs with insufficient evidence to make any recommendation. Conclusions: This clinical practice guideline provides evidence-based recommendations and identifies areas where further research is needed regarding transfusion practices and transfusion avoidance in non-bleeding, critically ill adults.
Original languageEnglish
Pages (from-to)1-24
Number of pages24
JournalIntensive Care Medicine
Volume2020
DOIs
Publication statusPublished - 2020

Keywords

  • Coagulopathy
  • Critically ill
  • EPO
  • Guideline
  • Intensive care
  • Plasma
  • Platelets
  • Point of care
  • Red blood cells
  • Transfusion

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