Transcriptome integration analysis and specific diagnosis model construction for Hodgkin's lymphoma, diffuse large B-cell lymphoma, and mantle cell lymphoma

Luca Tamagnone, L Wen-Xing, Shao-Xing Dai, San-Qi An, Tingting Sun, Justin Liu, Jun Wang, Leyna G Liu, Yang Xun, Hua Yang, Li-Xia Fan, Xiao-Li Zhang, Wan-Qin Liao, Hua You, Fang Liu, Jing-Fei Huang, Dahai Liu

Research output: Contribution to journalArticle

Abstract

Transcriptome differences between Hodgkin's lymphoma (HL), diffuse large B-cell lymphoma (DLBCL), and mantle cell lymphoma (MCL), which are all derived from B cell, remained unclear. This study aimed to construct lymphoma-specific diagnostic models by screening lymphoma marker genes. Transcriptome data of HL, DLBCL, and MCL were obtained from public databases. Lymphoma marker genes were screened by comparing cases and controls as well as the intergroup differences among lymphomas. A total of 9 HL marker genes, 7 DLBCL marker genes, and 4 MCL marker genes were screened in this study. Most HL marker genes were upregulated, whereas DLBCL and MCL marker genes were downregulated compared to controls. The optimal HL-specific diagnostic model contains one marker gene (MYH2) with an AUC of 0.901. The optimal DLBCL-specific diagnostic model contains 7 marker genes (LIPF, CCDC144B, PRO2964, PHF1, SFTPA2, NTS, and HP) with an AUC of 0.951. The optimal MCL-specific diagnostic model contains 3 marker genes (IGLV3-19, IGKV4-1, and PRB3) with an AUC of 0.843. The present study reveals the transcriptome data-based differences between HL, DLBCL, and MCL, when combined with other clinical markers, may help the clinical diagnosis and prognosis.
Original languageEnglish
Pages (from-to)1-24
Number of pages24
JournalAging
Volume13
DOIs
Publication statusPublished - 2021

Keywords

  • diagnostic model
  • intergroup difference
  • lymphoma
  • gene expression
  • marker gene

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