Toll-like receptor 4 mediates endothelial cell activation through NF-κB but is not associated with endothelial dysfunction in patients with rheumatoid arthritis

Angelo Zoli, Carmine Cardillo, Barbara Tolusso, Gianfranco Ferraccioli, R Menghini, U Campia, M Tesauro, A Marino, V Rovella, G Rodia, F Schinzari, N Di Daniele, M Federici

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

To investigate the effects of TLR4 antagonism on human endothelial cells activation and cytokine expression, and whether the Asp299Gly TLR4 polymorphism is associated with better endothelial function in patients with rheumatoid arthritis (RA).
Original languageEnglish
Pages (from-to)e99053-e99053
JournalPLoS One
Volume9
DOIs
Publication statusPublished - 2014

Keywords

  • Aorta
  • Arthritis, Rheumatoid
  • Cells, Cultured
  • Disaccharides
  • Endothelium, Vascular
  • Humans
  • Lipopolysaccharides
  • NF-kappa B
  • Phosphorylation
  • Sugar Phosphates
  • Toll-Like Receptor 4

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