TNFRSF11B gene polymorphisms increased risk of peripheral arterial occlusive disease and critical limb ischemia in patients with type 2 diabetes

Angelo Santoliquido, Paolo Tondi, Dario Pitocco, Antonio Gasbarrini, Andrea Flex, Federico Biscetti, Flavio Bertucci, Giuseppe Straface, Flavia Angelini, Luca Santoro, Raffaele Landolfi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Osteoprotegerin (OPG) is a secretory glycoprotein that belongs to the tumor necrosis factor receptor family and plays a role in atherosclerosis. OPG has been hypothesized to modulate vascular functions; however, its role in mediating atherosclerosis is controversial. Epidemiological data in patients with cardiovascular disease (CVD) indicate that OPG serum levels are associated with several inflammatory markers, myocardial infarction events, and calcium scores, suggesting that OPG may be causative for CVD.
Original languageEnglish
Pages (from-to)1025-1032
Number of pages8
JournalActa Diabetologica
Volume51
DOIs
Publication statusPublished - 2014

Keywords

  • peripheral arterial
  • type 2 diabetes

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