TNFRSF11B gene polymorphisms increased risk of peripheral arterial occlusive disease and critical limb ischemia in patients with type 2 diabetes

Federico Biscetti; Flavio Bertucci; Giuseppe Straface; Angelo Santoliquido; Paolo Tondi; Flavia Angelini; Dario Pitocco; Antonio Gasbarrini; Raffaele Landolfi; Andrea Flex

doi:10.1007/s00592-014-0664-1

TNFRSF11B gene polymorphisms increased risk of peripheral arterial occlusive disease and critical limb ischemia in patients with type 2 diabetes

Federico Biscetti, Flavio Bertucci, Giuseppe Straface, Angelo Santoliquido, Paolo Tondi, Flavia Angelini, Dario Pitocco, Antonio Gasbarrini, Raffaele Landolfi, Andrea Flex

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Osteoprotegerin (OPG) is a secretory glycoprotein that belongs to the tumor necrosis factor receptor family and plays a role in atherosclerosis. OPG has been hypothesized to modulate vascular functions; however, its role in mediating atherosclerosis is controversial. Epidemiological data in patients with cardiovascular disease (CVD) indicate that OPG serum levels are associated with several inflammatory markers, myocardial infarction events, and calcium scores, suggesting that OPG may be causative for CVD.

Original language	English
Pages (from-to)	1025-1032
Number of pages	8
Journal	Acta Diabetologica
DOIs	https://doi.org/10.1007/s00592-014-0664-1
Publication status	Published - 2014

Keywords

Atherosclerosis
Diabetes
Gene Polymorphism
Peripheral arterial disease

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00592-014-0664-1

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title = "TNFRSF11B gene polymorphisms increased risk of peripheral arterial occlusive disease and critical limb ischemia in patients with type 2 diabetes",

abstract = "Osteoprotegerin (OPG) is a secretory glycoprotein that belongs to the tumor necrosis factor receptor family and plays a role in atherosclerosis. OPG has been hypothesized to modulate vascular functions; however, its role in mediating atherosclerosis is controversial. Epidemiological data in patients with cardiovascular disease (CVD) indicate that OPG serum levels are associated with several inflammatory markers, myocardial infarction events, and calcium scores, suggesting that OPG may be causative for CVD.",

keywords = "Atherosclerosis, Diabetes, Gene Polymorphism, Peripheral arterial disease, Atherosclerosis, Diabetes, Gene Polymorphism, Peripheral arterial disease",

author = "Federico Biscetti and Flavio Bertucci and Giuseppe Straface and Angelo Santoliquido and Paolo Tondi and Flavia Angelini and Dario Pitocco and Antonio Gasbarrini and Raffaele Landolfi and Andrea Flex",

year = "2014",

doi = "10.1007/s00592-014-0664-1",

language = "English",

pages = "1025--1032",

journal = "Acta Diabetologica",

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TY - JOUR

T1 - TNFRSF11B gene polymorphisms increased risk of peripheral arterial occlusive disease and critical limb ischemia in patients with type 2 diabetes

AU - Biscetti, Federico

AU - Bertucci, Flavio

AU - Straface, Giuseppe

AU - Santoliquido, Angelo

AU - Tondi, Paolo

AU - Angelini, Flavia

AU - Pitocco, Dario

AU - Gasbarrini, Antonio

AU - Landolfi, Raffaele

AU - Flex, Andrea

PY - 2014

Y1 - 2014

N2 - Osteoprotegerin (OPG) is a secretory glycoprotein that belongs to the tumor necrosis factor receptor family and plays a role in atherosclerosis. OPG has been hypothesized to modulate vascular functions; however, its role in mediating atherosclerosis is controversial. Epidemiological data in patients with cardiovascular disease (CVD) indicate that OPG serum levels are associated with several inflammatory markers, myocardial infarction events, and calcium scores, suggesting that OPG may be causative for CVD.

AB - Osteoprotegerin (OPG) is a secretory glycoprotein that belongs to the tumor necrosis factor receptor family and plays a role in atherosclerosis. OPG has been hypothesized to modulate vascular functions; however, its role in mediating atherosclerosis is controversial. Epidemiological data in patients with cardiovascular disease (CVD) indicate that OPG serum levels are associated with several inflammatory markers, myocardial infarction events, and calcium scores, suggesting that OPG may be causative for CVD.

KW - Atherosclerosis

KW - Diabetes

KW - Gene Polymorphism

KW - Peripheral arterial disease

KW - Atherosclerosis

KW - Diabetes

KW - Gene Polymorphism

KW - Peripheral arterial disease

UR - http://hdl.handle.net/10807/60692

U2 - 10.1007/s00592-014-0664-1

DO - 10.1007/s00592-014-0664-1

M3 - Article

SN - 1432-5233

SP - 1025

EP - 1032

JO - Acta Diabetologica

JF - Acta Diabetologica

ER -

TNFRSF11B gene polymorphisms increased risk of peripheral arterial occlusive disease and critical limb ischemia in patients with type 2 diabetes

Abstract

Keywords

UN SDGs

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