Thyroid hormones and antioxidant systems: focus on oxidative stress in cardiovascular and pulmonary diseases

Andrea Silvestrini, Alfredo Pontecorvi, Elisabetta Meucci, Antonio Mancini, Sebastiano Raimondo, Roberto Festa, Luca Tiano

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

In previous works we demonstrated an inverse correlation between plasma Coenzyme Q10 (CoQ10) and thyroid hormones; in fact, CoQ10 levels in hyperthyroid patients were found among the lowest detected in human diseases. On the contrary, CoQ10 is elevated in hypothyroid subjects, also in subclinical conditions, suggesting the usefulness of this index in assessing metabolic status in thyroid disorders. A Low-T3 syndrome is a condition observed in several chronic diseases: it is considered an adaptation mechanism, where there is a reduction in pro-hormone T4 conversion. Low T3-Syndrome is not usually considered to be corrected with replacement therapy. We review the role of thyroid hormones in regulation of antioxidant systems, also presenting data on total antioxidant capacity and Coenzyme Q10. Published studies suggest that oxidative stress could be involved in the clinical course of different heart diseases; our data could support the rationale of replacement therapy in low-T3 conditions.
Original languageEnglish
Pages (from-to)23893-23909
Number of pages17
JournalInternational Journal of Molecular Sciences
Volume14
DOIs
Publication statusPublished - 2013

Keywords

  • antioxidant

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