The treatment of hyperinsulinemic hypoglycaemia in adults: an update

M. V. Davi′; A. Pia; V. Guarnotta; G. Pizza; A. Colao; A. Faggiano; null On Behalf Of Nike Group; Manuela Albertelli; Emanuela Arvat; Roberto Baldelli; Alfredo Berruti; Antonio Bianchi; Lisa Bodei; Gerardo Botti; Francesco Corcione; Gianfranco Delle Fave; Laura De Marinis; Laura De Marinis Grasso; Gaetano De Rosa; Antonella Di Sarno; Alessandra Dicitore; Nicola Fazio; Giuseppe Fanciulli; Piero Ferolla; Diego Ferone; Angelina Filice; Marco Gallo; Carla Giordano; Dario Giuffrida; Andrea Lania; Secondo Lastoria; Francesco Logoluso; Paola Loli; Pasqualino Malandrino; Marco Manzoni; Massimo Marchetti; Chiara Martini; Erika Messina; Roberta Modica; Cecilia Motta; Mauro Papotti; Stefano Partelli; Giovanni Persico; Alessandro Piovesan; Alfredo Pontecorvi; Valeria Ramundo; Paola Razzore; Francesca Rota; Francesco Scavuzzo; Concetta Sciammarella; Giovanni Vitale; Maria Chiara Zatelli

doi:10.1007/s40618-016-0536-3

The treatment of hyperinsulinemic hypoglycaemia in adults: an update

M. V. Davi′, A. Pia, V. Guarnotta, G. Pizza, A. Colao, A. Faggiano, On Behalf Of Nike Group, Manuela Albertelli, Emanuela Arvat, Roberto Baldelli, Alfredo Berruti, Antonio Bianchi, Lisa Bodei, Gerardo Botti, Francesco Corcione, Gianfranco Delle Fave, Laura De Marinis, Laura De Marinis Grasso, Gaetano De Rosa, Antonella Di SarnoAlessandra Dicitore, Nicola Fazio, Giuseppe Fanciulli, Piero Ferolla, Diego Ferone, Angelina Filice, Marco Gallo, Carla Giordano, Dario Giuffrida, Andrea Lania, Secondo Lastoria, Francesco Logoluso, Paola Loli, Pasqualino Malandrino, Marco Manzoni, Massimo Marchetti, Chiara Martini, Erika Messina, Roberta Modica, Cecilia Motta, Mauro Papotti, Stefano Partelli, Giovanni Persico, Alessandro Piovesan, Alfredo Pontecorvi, Valeria Ramundo, Paola Razzore, Francesca Rota, Francesco Scavuzzo, Concetta Sciammarella, Giovanni Vitale, Maria Chiara Zatelli

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20 Citations (Scopus)

Abstract

Background: Treatment of hyperinsulinemic hypoglycaemia (HH) is challenging due to the rarity of this condition and the difficulty of differential diagnosis. The aim of this article is to give an overview of the recent literature on the management of adult HH. Methods: A search for reviews, original articles, original case reports between 1995 and 2016 in PubMed using the following keywords: hyperinsulinemic hypoglycaemia, insulinoma, nesidioblastosis, gastric bypass, autoimmune hypoglycaemia, hyperinsulinism, treatment was performed. Results: One hundred and forty articles were selected and analysed focusing on the most recent treatments of HH. Conclusions: New approaches to treatment of HH are available including mini-invasive surgical techniques and alternative local–regional ablative therapy for benign insulinoma and everolimus for malignant insulinoma. A correct differential diagnosis is of paramount importance to avoid unnecessary surgical operations and to implement the appropriate treatment mainly in the uncommon forms of HH, such as nesidioblastosis and autoimmune hypoglycaemia.

Original language	English
Pages (from-to)	9-20
Number of pages	12
Journal	Journal of Endocrinological Investigation
Volume	40
DOIs	https://doi.org/10.1007/s40618-016-0536-3
Publication status	Published - 2017

Keywords

Autoimmune hypoglycaemia
Endocrinology
Endocrinology, Diabetes and Metabolism
Hyperinsulinemic hypoglycaemia
Insulinoma
Nesidioblastosis
Treatment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s40618-016-0536-3

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Davi′, M. V., Pia, A., Guarnotta, V., Pizza, G., Colao, A., Faggiano, A., On Behalf Of Nike Group, Albertelli, M., Arvat, E., Baldelli, R., Berruti, A., Bianchi, A., Bodei, L., Botti, G., Corcione, F., Delle Fave, G., De Marinis, L., De Marinis Grasso, L., De Rosa, G., ... Chiara Zatelli, M. (2017). The treatment of hyperinsulinemic hypoglycaemia in adults: an update. Journal of Endocrinological Investigation, 40, 9-20. https://doi.org/10.1007/s40618-016-0536-3

@article{8a7bd45407c547e1b316bf091f666fa5,

title = "The treatment of hyperinsulinemic hypoglycaemia in adults: an update",

abstract = "Background: Treatment of hyperinsulinemic hypoglycaemia (HH) is challenging due to the rarity of this condition and the difficulty of differential diagnosis. The aim of this article is to give an overview of the recent literature on the management of adult HH. Methods: A search for reviews, original articles, original case reports between 1995 and 2016 in PubMed using the following keywords: hyperinsulinemic hypoglycaemia, insulinoma, nesidioblastosis, gastric bypass, autoimmune hypoglycaemia, hyperinsulinism, treatment was performed. Results: One hundred and forty articles were selected and analysed focusing on the most recent treatments of HH. Conclusions: New approaches to treatment of HH are available including mini-invasive surgical techniques and alternative local–regional ablative therapy for benign insulinoma and everolimus for malignant insulinoma. A correct differential diagnosis is of paramount importance to avoid unnecessary surgical operations and to implement the appropriate treatment mainly in the uncommon forms of HH, such as nesidioblastosis and autoimmune hypoglycaemia.",

keywords = "Autoimmune hypoglycaemia, Endocrinology, Endocrinology, Diabetes and Metabolism, Hyperinsulinemic hypoglycaemia, Insulinoma, Nesidioblastosis, Treatment, Autoimmune hypoglycaemia, Endocrinology, Endocrinology, Diabetes and Metabolism, Hyperinsulinemic hypoglycaemia, Insulinoma, Nesidioblastosis, Treatment",

author = "Davi′, {M. V.} and A. Pia and V. Guarnotta and G. Pizza and A. Colao and A. Faggiano and {On Behalf Of Nike Group} and Manuela Albertelli and Emanuela Arvat and Roberto Baldelli and Alfredo Berruti and Antonio Bianchi and Lisa Bodei and Gerardo Botti and Francesco Corcione and {Delle Fave}, Gianfranco and {De Marinis}, Laura and {De Marinis Grasso}, Laura and {De Rosa}, Gaetano and {Di Sarno}, Antonella and Alessandra Dicitore and Nicola Fazio and Giuseppe Fanciulli and Piero Ferolla and Diego Ferone and Angelina Filice and Marco Gallo and Carla Giordano and Dario Giuffrida and Andrea Lania and Secondo Lastoria and Francesco Logoluso and Paola Loli and Pasqualino Malandrino and Marco Manzoni and Massimo Marchetti and Chiara Martini and Erika Messina and Roberta Modica and Cecilia Motta and Mauro Papotti and Stefano Partelli and Giovanni Persico and Alessandro Piovesan and Alfredo Pontecorvi and Valeria Ramundo and Paola Razzore and Francesca Rota and Francesco Scavuzzo and Concetta Sciammarella and Giovanni Vitale and {Chiara Zatelli}, Maria",

year = "2017",

doi = "10.1007/s40618-016-0536-3",

language = "English",

volume = "40",

pages = "9--20",

journal = "Journal of Endocrinological Investigation",

issn = "0391-4097",

publisher = "Springer Science and Business Media Deutschland GmbH",

}

Davi′, MV, Pia, A, Guarnotta, V, Pizza, G, Colao, A, Faggiano, A, On Behalf Of Nike Group, Albertelli, M, Arvat, E, Baldelli, R, Berruti, A, Bianchi, A, Bodei, L, Botti, G, Corcione, F, Delle Fave, G, De Marinis, L, De Marinis Grasso, L, De Rosa, G, Di Sarno, A, Dicitore, A, Fazio, N, Fanciulli, G, Ferolla, P, Ferone, D, Filice, A, Gallo, M, Giordano, C, Giuffrida, D, Lania, A, Lastoria, S, Logoluso, F, Loli, P, Malandrino, P, Manzoni, M, Marchetti, M, Martini, C, Messina, E, Modica, R, Motta, C, Papotti, M, Partelli, S, Persico, G, Piovesan, A, Pontecorvi, A, Ramundo, V, Razzore, P, Rota, F, Scavuzzo, F, Sciammarella, C, Vitale, G & Chiara Zatelli, M 2017, 'The treatment of hyperinsulinemic hypoglycaemia in adults: an update', Journal of Endocrinological Investigation, vol. 40, pp. 9-20. https://doi.org/10.1007/s40618-016-0536-3

TY - JOUR

T1 - The treatment of hyperinsulinemic hypoglycaemia in adults: an update

AU - Davi′, M. V.

AU - Pia, A.

AU - Guarnotta, V.

AU - Pizza, G.

AU - Colao, A.

AU - Faggiano, A.

AU - On Behalf Of Nike Group, null

AU - Albertelli, Manuela

AU - Arvat, Emanuela

AU - Baldelli, Roberto

AU - Berruti, Alfredo

AU - Bianchi, Antonio

AU - Bodei, Lisa

AU - Botti, Gerardo

AU - Corcione, Francesco

AU - Delle Fave, Gianfranco

AU - De Marinis, Laura

AU - De Marinis Grasso, Laura

AU - De Rosa, Gaetano

AU - Di Sarno, Antonella

AU - Dicitore, Alessandra

AU - Fazio, Nicola

AU - Fanciulli, Giuseppe

AU - Ferolla, Piero

AU - Ferone, Diego

AU - Filice, Angelina

AU - Gallo, Marco

AU - Giordano, Carla

AU - Giuffrida, Dario

AU - Lania, Andrea

AU - Lastoria, Secondo

AU - Logoluso, Francesco

AU - Loli, Paola

AU - Malandrino, Pasqualino

AU - Manzoni, Marco

AU - Marchetti, Massimo

AU - Martini, Chiara

AU - Messina, Erika

AU - Modica, Roberta

AU - Motta, Cecilia

AU - Papotti, Mauro

AU - Partelli, Stefano

AU - Persico, Giovanni

AU - Piovesan, Alessandro

AU - Pontecorvi, Alfredo

AU - Ramundo, Valeria

AU - Razzore, Paola

AU - Rota, Francesca

AU - Scavuzzo, Francesco

AU - Sciammarella, Concetta

AU - Vitale, Giovanni

AU - Chiara Zatelli, Maria

PY - 2017

Y1 - 2017

N2 - Background: Treatment of hyperinsulinemic hypoglycaemia (HH) is challenging due to the rarity of this condition and the difficulty of differential diagnosis. The aim of this article is to give an overview of the recent literature on the management of adult HH. Methods: A search for reviews, original articles, original case reports between 1995 and 2016 in PubMed using the following keywords: hyperinsulinemic hypoglycaemia, insulinoma, nesidioblastosis, gastric bypass, autoimmune hypoglycaemia, hyperinsulinism, treatment was performed. Results: One hundred and forty articles were selected and analysed focusing on the most recent treatments of HH. Conclusions: New approaches to treatment of HH are available including mini-invasive surgical techniques and alternative local–regional ablative therapy for benign insulinoma and everolimus for malignant insulinoma. A correct differential diagnosis is of paramount importance to avoid unnecessary surgical operations and to implement the appropriate treatment mainly in the uncommon forms of HH, such as nesidioblastosis and autoimmune hypoglycaemia.

AB - Background: Treatment of hyperinsulinemic hypoglycaemia (HH) is challenging due to the rarity of this condition and the difficulty of differential diagnosis. The aim of this article is to give an overview of the recent literature on the management of adult HH. Methods: A search for reviews, original articles, original case reports between 1995 and 2016 in PubMed using the following keywords: hyperinsulinemic hypoglycaemia, insulinoma, nesidioblastosis, gastric bypass, autoimmune hypoglycaemia, hyperinsulinism, treatment was performed. Results: One hundred and forty articles were selected and analysed focusing on the most recent treatments of HH. Conclusions: New approaches to treatment of HH are available including mini-invasive surgical techniques and alternative local–regional ablative therapy for benign insulinoma and everolimus for malignant insulinoma. A correct differential diagnosis is of paramount importance to avoid unnecessary surgical operations and to implement the appropriate treatment mainly in the uncommon forms of HH, such as nesidioblastosis and autoimmune hypoglycaemia.

KW - Autoimmune hypoglycaemia

KW - Endocrinology

KW - Endocrinology, Diabetes and Metabolism

KW - Hyperinsulinemic hypoglycaemia

KW - Insulinoma

KW - Nesidioblastosis

KW - Treatment

KW - Autoimmune hypoglycaemia

KW - Endocrinology

KW - Endocrinology, Diabetes and Metabolism

KW - Hyperinsulinemic hypoglycaemia

KW - Insulinoma

KW - Nesidioblastosis

KW - Treatment

UR - http://hdl.handle.net/10807/91875

UR - http://link.springer.com/journal/40618

U2 - 10.1007/s40618-016-0536-3

DO - 10.1007/s40618-016-0536-3

M3 - Article

SN - 0391-4097

VL - 40

SP - 9

EP - 20

JO - Journal of Endocrinological Investigation

JF - Journal of Endocrinological Investigation

ER -

The treatment of hyperinsulinemic hypoglycaemia in adults: an update

Abstract

Keywords

UN SDGs

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