The SURF (Italian observational study for renal insufficiency evaluation in liver transplant recipients): A post-hoc between-sex analysis

Alfonso Wolfango Avolio, Delia Colombo, Emanuela Zagni, Alessandro Zullo, Lucia Simoni, Stefano Fagiuoli, Paolo De Simone, Donato Donati, Mauro Salizzoni, Paolo Angeli, Patrizia Burra, Umberto Cillo, Pierluigi Toniutto, Massimo Rossi, Giovanni Vennarecci, Luciano De Carlis, Francesca Donato, Matteo Cescon, Alfredo Di Leo, Giovanni Giuseppe Di Costanzo

Research output: Contribution to journalArticle

Abstract

Background: Female sex has been reported as an independent predictor of severe post-liver transplantation (LT) chronic kidney disease. We performed a by sex post-hoc analysis of the SURF study, that investigated the prevalence of renal impairment following LT, aimed at exploring possible differences between sexes in the prevalence and course of post-LT renal damage. Methods: All patients enrolled in the SURF study were considered evaluable for this sex-based analysis, whose primary objective was to evaluate by sex the proportion of patients with estimated Glomerular Filtration Rate (eGFR) < 60 ml/min/1.73m2 at inclusion and follow-up visit. Results: Seven hundred thirty-eight patients were included in our analysis, 76% males. The proportion of patients with eGFR < 60 mL/min/1.73 m2 was significantly higher in females at initial study visit (33.3 vs 22.8%; p = 0.005), but also before, at time of transplantation (22.9 vs 14.7%; p = 0.0159), as analyzed retrospectively. At follow-up, such proportion increased more in males than in females (33.9 vs 26.0%, p = 0.04). Mean eGFR values decreased over the study in both sexes, with no significant differences. Statistically significant M/F differences in patient distribution by O'Riordan eGFR levels were observed at time of transplant and study initial visit (p = 0.0005 and 0.0299 respectively), but not at follow-up. Conclusions: Though the limitation of being performed post-hoc, this analysis suggests potential sex differences in the prevalence of renal impairment before and after LT, encouraging further clinical research to explore such differences more in depth.
Original languageEnglish
Pages (from-to)475-475
Number of pages1
JournalBMC Nephrology
Volume20
DOIs
Publication statusPublished - 2019

Keywords

  • Adult
  • Aged
  • Calcineurin inhibitors
  • Cross-Sectional Studies
  • Female
  • Follow-Up Studies
  • Gender
  • Glomerular Filtration Rate
  • Humans
  • Italy
  • Liver Transplantation
  • Liver transplant
  • Longitudinal Studies
  • Male
  • Meta-analysis
  • Middle Aged
  • Renal Insufficiency
  • Renal insufficiency
  • Retrospective Studies
  • Sex Characteristics
  • Sex differences
  • Transplant Recipients

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