The safety of calcium channel blockers during pregnancy: a prospective, multicenter, observational study.

Marco De Santis, C Weber Schoendorfer, D Hannemann, R Meister, E Eléfant, B Cuppers Maarschalkerweerd, J Arnon, T Vial, E Rodriguez Pinilla, M Clementi, E Robert Gnansia, H Malm, A Dolivo, C. Schaefer

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

OBJECTIVE: To assess the safety of calcium channel blockers during the first trimester of pregnancy. STUDY DESIGN: A multicenter (n=11), prospective observational study of the European Network of Teratology Information Services (ENTIS). The rate of major birth defects was compared between a cohort of pregnant women exposed to calcium channel blockers during the first trimester (n=299) and a control group not exposed to potential teratogens (n=806). RESULTS: Major birth defects were not more common in the study group than in the control group. Birth weight was significantly lower in exposed term newborns. There were more preterm infants in the study group than in the control group (23.8% vs. 6.5%). These adverse effects are more likely due to the underlying disease than to the medication. CONCLUSION: This study suggests that calcium channel blockers during the first trimester of pregnancy do not represent a major teratogenic risk.
Original languageEnglish
Pages (from-to)24-30
Number of pages7
JournalReproductive Toxicology
Publication statusPublished - 2008

Keywords

  • calcium channel blockers
  • pregnancy:
  • teratology

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