The Role of the Stem Cells Therapy in the Peripheral Artery Disease.

Federico Biscetti*, Nicola Bonadia, Elisabetta Nardella, Andrea Leonardo Cecchini, Raffaele Landolfi, Andrea Flex

*Corresponding author

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Vascular complications of diabetes mellitus are an important issue for all clinicians involved in the management of this complex pathology. Although many therapeutic advances have been reached, peripheral arterial disease is still an unsolved problem that each year compromises the quality of life and life span of affected patients. Oftentimes, patients, after ineffective attempts of revascularization, undergo greater amputations. At the moment, there is no effective and definitive treatment available. In this scenario, the therapeutic use of stem cells could be an interesting option. The aim of the present review is to gather all the best available evidence in this regard and to define a new role of the stem cells therapy in this field, from biomarker to possible therapeutic target.
Original languageEnglish
Pages (from-to)2233-2244
Number of pages12
JournalInternational Journal of Molecular Sciences
Volume2019
DOIs
Publication statusPublished - 2019

Keywords

  • Stem cells therapy
  • lower limb peripheral artery disease
  • type 2 diabetes mellitus

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