The role of caveolin-1 in the regulation of angiogenesis

Alessio D'Alessio, Gigliola Sica

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Caveolin-1 (cav-1) is the principal structural component of caveolae which functions as scaffoldiprotein for the integration of a variety of signaling pathways. In this study, we show that siRNA-induced cav-1 down regulation in human endothelial cells (EC) increased cell size and provoked cell cycle arrest at G1/S phase transition. In addition, silencing of cav-1 reduced matrix metalloproteinases (MMPs) activity which, in turn, affected cell migration and VEGF-induced tube formation of EC in vitro. These data indicate that proper expression of cav-1 is required for maintaining typical functions of EC such as proliferation and the formation of new blood vessels. In addition, we observed a marked increase of cell size, after cav-1 silencing, which might indicate the involvement of this scaffolding protein in the way by which cells perceive changes in their microenvironment. In conclusion, this study proposes cav-1 as an interesting target molecule for studying cellular mechanisms which occur in physiological as well as pathological conditions such as senescence and tumorigenesis.
Original languageEnglish
Title of host publicationITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY
Pages53
Number of pages1
Publication statusPublished - 2012
EventCONGRESSO NAZIONALE DELLA SOCIETA' ITALIANA DI ANATOMIA E ISTOLOGIA (SIAI) - Pistoia
Duration: 20 Sep 201223 Sep 2012

Conference

ConferenceCONGRESSO NAZIONALE DELLA SOCIETA' ITALIANA DI ANATOMIA E ISTOLOGIA (SIAI)
CityPistoia
Period20/9/1223/9/12

Keywords

  • CAVEOLIN

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