The Proteolytic Systems of Muscle Wasting

Bianca Maria Scicchitano, Martina Faraldi, Antonio Musarò

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Skeletal muscle represents one of the most plastic tissues of our body thanks to the presence of heterogeneous population of myofibers that confer to skeletal muscle the functional plasticity necessary to modulate its morpho-fuctional properties in response to a wide range of external factors. Thus, alteration in fiber type composition represents a major component in muscle wasting associated with muscle diseases. Several mechanisms have been proposed to account for the alteration in the morpho-functional properties of skeletal muscle under pathological conditions. In this review we will discuss the potential catabolic mediators of muscle atrophy and wasting.
Original languageEnglish
Pages (from-to)26-35
Number of pages10
JournalRECENT ADVANCES IN DNA & GENE SEQUENCES
Volume9
Publication statusPublished - 2015

Keywords

  • Autophagy
  • calpain

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