The pathogenic role of autoantibodies in recurrent pregnancy loss

Antonio Lanzone, Giovanni Scambia, Silvia D'Ippolito, Chiara Tersigni, Serafina Garofalo, Carmelinda Martino, Nicoletta Di Simone, Carlo Ticconi

Research output: Contribution to journalArticle

7 Citations (Scopus)


In the present manuscript, we review the recent research investigating the pathogenic association between most studied autoantibodies and recurrent pregnancy loss. Pregnancy loss represents a common obstetric complication occurring in about 15%-25% of all clinically recognized pregnancies. The recurrence of pregnancy loss identifies a distinct clinical entity, that is recurrent pregnancy loss (RPL), affecting about 2%-4% of couples. Several factors, including age, chromosomal abnormalities, uterine anomalies, thrombophilic disorders, endocrinopathies, hormonal and metabolic disorders, infections, sperm quality, and lifestyle issues, are involved in RPL. The role of autoantibodies in RPL is only partially determined. In some cases (antiphospholipid antibodies [aPL]), their involvement is well established. In other cases (anti-thyroid autoantibodies, antinuclear, anti-transglutaminase, and anti-endomysial antibodies), it is still debated, despite multiple, although not fully conclusive, evidences strongly suggest a possible involvement in RPL. Further extensive research is needed to definitively confirm or exclude their actual role.
Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalAmerican Journal of Reproductive Immunology
Publication statusPublished - 2020


  • anti-thyroid antibodies
  • antinuclear antibodies
  • antiphospholipid antibodies
  • celiac disease
  • miscarriage
  • recurrent pregnancy loss


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