The metabolic role of gut microbiota in the development of nonalcoholic fatty liver disease and cardiovascular disease

Antonio Gasbarrini, Antonio Grieco, Luca Miele, Giuseppe Marrone, Marco Sanduzzi Zamparelli, Debora Compare, Pietro Coccoli, Alba Rocco, Olga Maria Nardone

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The prevalence of metabolic disorders, such as type 2 diabetes (T2D), obesity, and non-alcoholic fatty liver disease (NAFLD), which are common risk factors for cardiovascular disease (CVD), has dramatically increased worldwide over the last decades. Although dietary habit is the main etiologic factor, there is an imperfect correlation between dietary habits and the development of metabolic disease. Recently, research has focused on the role of the microbiome in the development of these disorders. Indeed, gut microbiota is implicated in many metabolic functions and an altered gut microbiota is reported in metabolic disorders. Here we provide evidence linking gut microbiota and metabolic diseases, focusing on the pathogenetic mechanisms underlying this association.
Original languageEnglish
Pages (from-to)1225-N/A
JournalInternational Journal of Molecular Sciences
Volume17
DOIs
Publication statusPublished - 2016

Keywords

  • Cardiovascular disease
  • Catalysis
  • Computer Science Applications1707 Computer Vision and Pattern Recognition
  • Gut microbiota
  • Inorganic Chemistry
  • Molecular Biology
  • NAFLD
  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Spectroscopy

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