Abstract

Over the past recent years, a great number of studies have been directed toward the evaluation of the human host–gut microbiota interaction, with the goal to progress the understanding of the etiology of several complex diseases. Alterations in the intestinal microbiota associatedwith inflammatory bowel disease are well supported by literature data and have been widely accepted by the research community. The concomitant implementation of high-throughput sequencing techniques to analyze and characterize the composition of the intestinal microbiota has reinforced the view that inflammatory bowel disease results from altered interactions between gut microbes and the mucosal immune system and has raised the possibility that some form of modulation of the intestinal microbiota may constitute a potential therapeutic basis for the disease. The aim of this review is to describe the changes of gutmicrobiota in inflammatory bowel disease, focusing the attention on its involvement in the pathogenesis of the disease, and to review and discuss the therapeutic potential to modify the intestinal microbial population with antibiotics, probiotics, prebiotics, synbiotics and fecal microbiota transplantation.
Original languageEnglish
Pages (from-to)191-212
Number of pages22
JournalPHARMACOLOGY & THERAPEUTICS
Volume149
DOIs
Publication statusPublished - 2015

Keywords

  • Fecal microbiota transplantation
  • Gut microbiota
  • Inflammatory bowel disease
  • Metagenomics
  • Probiotics

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