The hedgehog signaling pathway in ischemic tissues

Eleonora Gaetani, Paolo Tondi, Roberto Pola, Igor Giarretta, Takayuki Asahara

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Hedgehog (Hh) proteins are prototypical morphogens known to regulate epithelial/mesenchymal interactions during embryonic development. In addition to its pivotal role in embryogenesis, the Hh signaling pathway may be recapitulated in post-natal life in a number of physiological and pathological conditions, including ischemia. This review highlights the involvement of Hh signaling in ischemic tissue regeneration and angiogenesis, with particular attention to the heart, the brain, and the skeletal muscle. Updated information on the potential role of the Hh pathway as a therapeutic target in the ischemic condition is also presented.
Original languageEnglish
Pages (from-to)5270-N/A
JournalInternational Journal of Molecular Sciences
Volume20
DOIs
Publication statusPublished - 2019

Keywords

  • Animals
  • Brain
  • Heart
  • Hedgehog
  • Hedgehog Proteins
  • Humans
  • Ischemia
  • Muscle, Skeletal
  • Myocardium
  • Signal Transduction
  • Skeletal muscle

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